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Tbio
SGSH
N-sulphoglucosamine sulphohydrolase

Protein Classes
Protein Summary
Description
Catalyzes a step in lysosomal heparan sulfate degradation. This gene encodes the enzyme sulfamidase; one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with the lysosomal storage disease mucopolysaccaridosis IIIA, also known as Sanfilippo syndrome A, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326317
  • ENSP00000314606
  • ENSG00000181523

Symbol
  • HSS
  • HSS
  • SFMD
  • MPS3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.92
histone modification site profile
0.86
kinase perturbation
0.76
virus perturbation
0.76
tissue sample
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.41   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.41   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-sulfoglucosamine sulfohydrolase
VGNC:51733
745502
Macaque
N-sulfoglucosamine sulfohydrolase
717977
Mouse
MGI:1350341
27029
Dog
N-sulfoglucosamine sulfohydrolase
VGNC:46104
403707
Horse
N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol;Acc:HGNC:10818]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-sulfoglucosamine sulfohydrolase
Macaque
N-sulfoglucosamine sulfohydrolase
Mouse
Dog
N-sulfoglucosamine sulfohydrolase
Horse
N-sulfoglucosamine sulfohydrolase [Source:HGNC Symbol;Acc:HGNC:10818]
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG degradation
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycosaminoglycan metabolism
HS-GAG degradation
Protein-Protein Interactions (46)
1 – 10 of 46
SUMF1
Tbio
Family: Enzyme
Novelty: 0.00954537
p_int: 0.999261981
p_ni: 0.000738018
p_wrong: 1e-9
Score: 0.869
Data Source: BioPlex,STRINGDB
FBXO6
Tbio
Novelty: 0.02173918
p_int: 0.984609767
p_ni: 0.015390233
Score: 0.219
Data Source: BioPlex,STRINGDB
NMD3
Tbio
Novelty: 0.03505289
p_int: 0.978359843
p_ni: 0.020909816
p_wrong: 0.000730341
Data Source: BioPlex
FBXO21
Tbio
Novelty: 0.2186203
p_int: 0.964534675
p_ni: 0.035465319
p_wrong: 6e-9
Data Source: BioPlex
NGLY1
Tbio
Family: Enzyme
Novelty: 0.01017395
p_int: 0.959269562
p_ni: 0.040730438
Data Source: BioPlex
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.935057932
p_ni: 0.064942068
Score: 0.166
Data Source: BioPlex,STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
p_int: 0.840506735
p_ni: 0.159493265
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.795377122
p_ni: 0.204622878
Data Source: BioPlex
HGSNAT
Tbio
Family: Enzyme
Novelty: 0.03264423
Score: 0.969
Data Source: STRINGDB
IDUA
Tbio
Family: Enzyme
Novelty: 0.00288117
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  161.41

PubMed score by year
PubTator Score  80.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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