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Tbio
NSD3
Histone-lysine N-methyltransferase NSD3

Protein Summary
Description
Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316985
  • ENSP00000313410
  • ENSG00000147548
  • ENST00000317025
  • ENSP00000313983
  • ENST00000433384
  • ENSP00000393284
  • ENST00000527502
  • ENSP00000434730

Symbol
  • WHSC1L1
  • KMT3F
  • KMT3G
  • WHISTLE
  • WHSC1L1
  • pp14328
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.99   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.99   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
84.2
systolic blood pressure
1
1
1
61.2
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
84.2
systolic blood pressure
1
61.2
0
1.1
31.4
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Protein-Protein Interactions (98)
1 – 10 of 98
BRD4
Tchem
Family: Epigenetic
Novelty: 0.0013933
Score: 0.885
Data Source: STRINGDB
BOD1L1
Tdark
Novelty: 0.26485597
Score: 0.773
Data Source: STRINGDB
BPTF
Tchem
Family: Epigenetic
Novelty: 0.00826037
Score: 0.719
Data Source: STRINGDB
CAMKMT
Tbio
Family: Enzyme
Novelty: 0.00382649
Score: 0.707
Data Source: STRINGDB
CHD8
Tbio
Family: Epigenetic
Novelty: 0.01177693
Score: 0.704
Data Source: STRINGDB
KDM1B
Tbio
Family: Epigenetic
Novelty: 0.02174039
Score: 0.69
Data Source: STRINGDB
PLPP5
Tbio
Family: Enzyme
Novelty: 0.14757412
Score: 0.679
Data Source: STRINGDB
PSIP1
Tchem
Family: Epigenetic
Novelty: 0.00216601
Score: 0.678
Data Source: STRINGDB
BRD3
Tchem
Family: Epigenetic
Novelty: 0.00335409
Score: 0.673
Data Source: STRINGDB
SETBP1
Tbio
Novelty: 0.00304173
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.99

PubMed score by year
PubTator Score  21.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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