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Tbio
NPHP1
Nephrocystin-1

Protein Summary
Description
Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localize ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316534
  • ENSP00000313169
  • ENSG00000144061
  • ENST00000355301
  • ENSP00000347452
  • ENST00000393272
  • ENSP00000376953
  • ENST00000445609
  • ENSP00000389879

Symbol
  • NPH1
  • NPH1
  • JBTS4
  • SLSN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.82
cell type or tissue
0.75
cellular component
0.72
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.69   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.69   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (201)
1 – 10 of 201
KCNA5
Tclin
Family: IC
Novelty: 0.00228979
p_int: 0.999984928
p_ni: 0.000014997
p_wrong: 7.5e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.04973432
p_int: 0.999979188
p_ni: 0.000020218
p_wrong: 5.93e-7
Data Source: BioPlex
RPGR
Tbio
Family: Enzyme
Novelty: 0.00353224
p_int: 0.99992892
p_ni: 0.000056743
p_wrong: 0.000014336
Score: 0.948
Data Source: BioPlex,STRINGDB
NPHP4
Tbio
Novelty: 0.03648525
Score: 0.999
Data Source: Reactome,STRINGDB
AHI1
Tbio
Novelty: 0.01007029
Score: 0.995
Data Source: STRINGDB
RPGRIP1L
Tbio
Novelty: 0.00525241
Score: 0.993
Data Source: Reactome,STRINGDB
TMEM67
Tbio
Novelty: 0.03031871
Score: 0.992
Data Source: STRINGDB
CEP290
Tbio
Novelty: 0.0076763
Score: 0.991
Data Source: STRINGDB
CC2D2A
Tbio
Novelty: 0.05964982
Score: 0.99
Data Source: STRINGDB
TMEM216
Tdark
Novelty: 0.22815754
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  62.69

PubMed score by year
PubTator Score  73.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer