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Tdark
SPACA4
Sperm acrosome membrane-associated protein 4

Protein Summary
Description
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321762
  • ENSP00000312774
  • ENSG00000177202

Symbol
  • SAMP14
  • SAMP14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
gene perturbation
0.59
cell line
0.52
transcription factor
0.39
cellular component
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.24   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.24   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (117)
1 – 10 of 117
MVK
Tchem
Family: Kinase
Novelty: 0.00328607
p_int: 0.995511276
p_ni: 0.004488509
p_wrong: 2.14e-7
Score: 0.519
Data Source: BioPlex,STRINGDB
GRN
Tbio
Novelty: 0.00096395
p_int: 0.958227671
p_ni: 0.041772329
Score: 0.158
Data Source: BioPlex,STRINGDB
NIF3L1
Tbio
Novelty: 0.15581813
p_int: 0.914131048
p_ni: 0.085868949
p_wrong: 3e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.838740639
p_ni: 0.161259361
Data Source: BioPlex
GALNS
Tbio
Family: Enzyme
Novelty: 0.00510529
p_int: 0.778776095
p_ni: 0.221206702
p_wrong: 0.000017203
Score: 0.179
Data Source: BioPlex,STRINGDB
NLN
Tbio
Family: Enzyme
Novelty: 0.01217367
p_int: 0.776362261
p_ni: 0.223637739
Score: 0.345
Data Source: BioPlex,STRINGDB
TEX101
Tbio
Novelty: 0.03488625
Score: 0.968
Data Source: STRINGDB
LYPD5
Tdark
Novelty: 0.97576337
Score: 0.955
Data Source: STRINGDB
LY6K
Tbio
Novelty: 0.01861325
Score: 0.955
Data Source: STRINGDB
LYPD2
Tdark
Novelty: 0.55307434
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.24

PubMed score by year
PubTator Score  2.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer