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Tchem
CAMKK2
Calcium/calmodulin-dependent protein kinase kinase 2

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324774
  • ENSP00000312741
  • ENSG00000110931
  • ENST00000337174
  • ENSP00000336634
  • ENST00000347034
  • ENSP00000321230
  • ENST00000392473
  • ENSP00000376265
  • ENST00000392474
  • ENSP00000376266
  • ENST00000402834
  • ENSP00000384591
  • ENST00000404169
  • ENSP00000384600
  • ENST00000412367
  • ENSP00000388368
  • ENST00000446440
  • ENSP00000388273
  • ENST00000538733
  • ENSP00000445944

Symbol
  • CAMKKB
  • KIAA0787
  • CAMKK
  • CAMKKB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
virus perturbation
0.94
kinase perturbation
0.88
protein domain
0.85
interacting protein
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.21   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 369   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.21   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
4
4
98.4
1
1
0
1.1
16.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
98.4
0
1.1
16.3
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Activation of AMPK downstream of NMDARs (R-HSA-9619483)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1 downstream of NMDARs
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Name
Explore in Pharos
Explore in Source
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of RAC1 downstream of NMDARs
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (65)
1 – 10 of 65
HINT1
Tbio
Novelty: 0.00815168
p_int: 0.999999909
p_ni: 9.1e-8
Data Source: BioPlex
GCHFR
Tbio
Family: Enzyme
Novelty: 0.04287433
p_int: 0.999997683
p_ni: 0.000002283
p_wrong: 3.4e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999986565
p_ni: 0.000013409
p_wrong: 2.6e-8
Score: 0.657
Data Source: BioPlex,STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.998931849
p_ni: 0.000800329
p_wrong: 0.000267822
Score: 0.185
Data Source: BioPlex,STRINGDB
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.998903756
p_ni: 0.001075597
p_wrong: 0.000020647
Data Source: BioPlex
INSYN2
Tdark
Novelty: 2.55244594
p_int: 0.857125352
p_ni: 0.00024663
p_wrong: 0.142628018
Score: 0.175
Data Source: BioPlex,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.992
Data Source: Reactome,STRINGDB
CAMK4
Tbio
Family: Kinase
Novelty: 0.00412444
Score: 0.962
Data Source: Reactome,STRINGDB
PRKAA2
Tchem
Family: Kinase
Novelty: 0.01795523
Score: 0.937
Data Source: Reactome,STRINGDB
PRKAG1
Tbio
Family: Kinase
Novelty: 0.07735301
Score: 0.934
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  224.21

PubMed score by year
PubTator Score  113.75

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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