Pharos: Illuminating the Druggable Genome

Tbio

Protein Classes

Protein Summary

Description

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placenta ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000323322
ENSP00000312673
ENSG00000259384
ENST00000351388
ENSP00000343791
ENST00000458650
ENSP00000408486

Symbol

GH
GHN
GH-N
GHB5
IGHD2
hGH-N
IGHD1A
IGHD1B

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.94

disease	0.9

biological process	0.88

phenotype	0.75

biological term	0.64

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1063.35 (req: < 5)

View Publications

Gene RIFs: 337 (req: <= 3)

View Gene RIFs

Antibodies: 1244 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1063.35 (req: >= 5)

Gene RIFs: 337 (req: > 3)

Antibodies: 1244 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (9)

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (92)

Reactome (7)

KEGG (4)

PathwayCommons (7)

WikiPathways (74)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 7

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Growth hormone receptor signaling	24 targets	R-HSA-982772

Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Reactome	Peptide hormone metabolism	88 targets	R-HSA-2980736

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Growth hormone receptor signaling	24 targets	R-HSA-982772

Immune System	2246 targets	R-HSA-168256

Metabolism of proteins	2050 targets	R-HSA-392499

Peptide hormone metabolism	88 targets	R-HSA-2980736

Gene Ontology Terms (25)

Functions (5)

Components (4)

Processes (16)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
growth hormone receptor binding	Inferred from Direct Assay (IDA)	MGI

prolactin receptor binding	Inferred from Direct Assay (IDA)	AgBase

growth factor activity	Inferred from Physical Interaction (IPI)	BHF-UCL

hormone activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (128)

1 – 10 of 128

See Interactions on String-DB

CSH1

Tbio

Novelty: 0.00110788

p_int: 1

Score: 0.976

Data Source: BioPlex,Reactome,STRINGDB

GHR

Tclin

Novelty: 0.00119399

Score: 0.996