You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BTN2A1
Butyrophilin subfamily 2 member A1

Protein Summary
Description
This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312541
  • ENSP00000312158
  • ENSG00000112763
  • ENST00000429381
  • ENSP00000416945
  • ENST00000469185
  • ENSP00000419043
  • ENST00000541522
  • ENSP00000443909

Symbol
  • BT2.1
  • BTF1
  • BTF1
  • BT2.1
  • BTN2.1
  • DJ3E1.1
  • BK14H9.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
0.76
phenotype
0.6
tissue sample
0.58
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.1   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.1   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
1
1
86.5
heel bone mineral density
1
1
1
76.2
unipolar depression
1
1
0
5.8
58.9
intelligence
2
2
1
6
49.3
neuroticism measurement
1
1
1
46.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
wellbeing measurement
1
86.5
heel bone mineral density
1
76.2
unipolar depression
0
5.8
58.9
intelligence
1
6
49.3
neuroticism measurement
1
46.7
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Butyrophilin (BTN) family interactions
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Butyrophilin (BTN) family interactions
Immune System
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (34)
1 – 10 of 34
BTN2A2
Tdark
Novelty: 0.46565474
p_int: 1
Score: 0.289
Data Source: BioPlex,STRINGDB
BLZF1
Tbio
Novelty: 0.04344183
p_int: 0.999985318
p_ni: 0.000014682
Score: 0.183
Data Source: BioPlex,STRINGDB
PLCB1
Tbio
Family: Enzyme
Novelty: 0.00269771
p_int: 0.999955201
p_ni: 0.000034638
p_wrong: 0.000010161
Score: 0.187
Data Source: BioPlex,STRINGDB
FAM171A2
Tdark
Novelty: 1.18763693
p_int: 0.999010225
p_ni: 0.000989771
p_wrong: 3e-9
Data Source: BioPlex
TMX4
Tdark
Novelty: 0.2628295
p_int: 0.998066269
p_ni: 0.001933731
Data Source: BioPlex
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.996954299
p_ni: 0.003045701
Data Source: BioPlex
TYW1
Tbio
Family: Enzyme
Novelty: 0.05117274
p_int: 0.99642715
p_ni: 0.00357285
Data Source: BioPlex
RAB3GAP1
Tbio
Family: Enzyme
Novelty: 0.0286836
p_int: 0.995622611
p_ni: 0.004377389
Data Source: BioPlex
DENND6A
Tbio
Novelty: 4.5572617
p_int: 0.993338119
p_ni: 0.006660443
p_wrong: 0.000001438
Data Source: BioPlex
PDZD8
Tbio
Novelty: 0.09015543
p_int: 0.991702603
p_ni: 0.008297397
Data Source: BioPlex
Publication Statistics
PubMed Score  44.10

PubMed score by year
PubTator Score  19.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: