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Tchem
CMKLR1
Chemokine-like receptor 1

Protein Summary
Description
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312143
  • ENSP00000311733
  • ENSG00000174600
  • ENST00000412676
  • ENSP00000401293
  • ENST00000550402
  • ENSP00000449716
  • ENST00000552995
  • ENSP00000447579

Symbol
  • CHEMR23
  • DEZ
  • DEZ
  • RVER1
  • ChemR23
  • CHEMERINR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.87
biological process
0.64
tissue sample
0.61
cell line
0.6
PubMedID
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.99   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 537   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.99   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 537   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
82.7
monocyte percentage of leukocytes
2
1
2
60.9
balding measurement
1
1
1
60.6
granulocyte percentage of myeloid white cells
1
1
1
29.2
smoking status measurement
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
82.7
monocyte percentage of leukocytes
2
60.9
balding measurement
1
60.6
granulocyte percentage of myeloid white cells
1
29.2
smoking status measurement
1
4.3
Pathways (5)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (102)
1 – 10 of 102
ROBO1
Tbio
Novelty: 0.00494884
p_int: 0.999981953
p_ni: 0.000014718
p_wrong: 0.000003329
Data Source: BioPlex
CST1
Tbio
Novelty: 0.02399609
p_int: 0.999775395
p_ni: 0.000153907
p_wrong: 0.000070698
Data Source: BioPlex
RAB5IF
Tdark
Novelty: 0.66468447
p_int: 0.999638048
p_ni: 0.000202924
p_wrong: 0.000159028
Data Source: BioPlex
STXBP2
Tbio
Novelty: 0.01896992
p_int: 0.999534358
p_ni: 0.000465642
Data Source: BioPlex
HELLS
Tbio
Family: Enzyme
Novelty: 0.01348077
p_int: 0.999373749
p_ni: 0.000626251
Data Source: BioPlex
PDXDC1
Tbio
Family: Enzyme
Novelty: 0.16529476
p_int: 0.998974365
p_ni: 0.001025635
Data Source: BioPlex
PDS5A
Tbio
Novelty: 0.0142948
p_int: 0.998665936
p_ni: 0.001334064
Data Source: BioPlex
TMEM186
Tdark
Novelty: 0.59951294
p_int: 0.998473114
p_ni: 0.001526505
p_wrong: 3.81e-7
Data Source: BioPlex
PDS5B
Tbio
Novelty: 0.00295057
p_int: 0.99675506
p_ni: 0.00324494
Data Source: BioPlex
SLC25A24
Tbio
Family: Transporter
Novelty: 0.06151955
p_int: 0.994442235
p_ni: 0.005553542
p_wrong: 0.000004223
Data Source: BioPlex
Publication Statistics
PubMed Score  124.99

PubMed score by year
PubTator Score  64.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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