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Tbio
PPP1R8
Nuclear inhibitor of protein phosphatase 1

Protein Summary
Description
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236412
  • ENSP00000236412
  • ENSG00000117751
  • ENST00000311772
  • ENSP00000311677
  • ENST00000373931
  • ENSP00000363042

Symbol
  • ARD1
  • NIPP1
  • ARD1
  • ARD-1
  • NIPP1
  • NIPP-1
  • PRO2047
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
kinase perturbation
0.93
molecular function
0.81
transcription factor perturbation
0.8
hub protein
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.81   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 361   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.81   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
1.6
myeloid white cell count
1
1
1
0.6
granulocyte count
1
1
1
0.6
sum of basophil and neutrophil counts
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1.6
myeloid white cell count
1
0.6
granulocyte count
1
0.6
sum of basophil and neutrophil counts
1
0.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 8
VGNC:6961
469247
Mouse
MGI:2140494
100336
Rat
RGD:1306280
313030
Horse
protein phosphatase 1 regulatory subunit 8
VGNC:21771
100056729
Cow
protein phosphatase 1 regulatory subunit 8
VGNC:33249
282319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 8
Mouse
Rat
Horse
protein phosphatase 1 regulatory subunit 8
Cow
protein phosphatase 1 regulatory subunit 8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (97)
1 – 10 of 97
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 1
Score: 0.982
Data Source: BioPlex,STRINGDB
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999997
p_ni: 3e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
RIPK2
Tchem
Family: Kinase
Novelty: 0.00574043
p_int: 0.998443594
p_ni: 0.001553115
p_wrong: 0.000003291
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.988592242
p_ni: 0.011407758
Data Source: BioPlex
USP47
Tchem
Family: Enzyme
Novelty: 0.07579226
p_int: 0.974011528
p_ni: 0.025988464
p_wrong: 8e-9
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.955415371
p_ni: 0.044584629
Score: 0.184
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.945529412
p_ni: 0.054470558
p_wrong: 3.1e-8
Score: 0.427
Data Source: BioPlex,STRINGDB
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.938376646
p_ni: 0.057366735
p_wrong: 0.004256619
Score: 0.167
Data Source: BioPlex,STRINGDB
PNPT1
Tbio
Family: Enzyme
Novelty: 0.00339969
Score: 0.959
Data Source: STRINGDB
PPP1R3B
Tbio
Family: Enzyme
Novelty: 0.0244434
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  787.81

PubMed score by year
PubTator Score  82.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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