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Tbio
DSCR3
Down syndrome critical region protein 3

Protein Classes
Protein Summary
Description
The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and cognitive disability. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309117
  • ENSP00000311399
  • ENSG00000157538
  • ENST00000476950
  • ENSP00000419496

Symbol
  • DCRA
  • DSCRA
  • DCRA
  • DSCR3
  • DSCRA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (73)
1 – 10 of 73
COMMD8
Tdark
Novelty: 0.33240242
p_int: 0.999999287
p_ni: 7.13e-7
Score: 0.812
Data Source: BioPlex,STRINGDB
VPS29
Tbio
Novelty: 0.01335106
p_int: 0.999994393
p_ni: 0.000005607
Score: 0.969
Data Source: BioPlex,STRINGDB
COMMD3
Tbio
Novelty: 0.07399068
p_int: 0.999991225
p_ni: 0.000008775
Score: 0.83
Data Source: BioPlex,STRINGDB
COMMD1
Tbio
Novelty: 0.01349432
p_int: 0.999985351
p_ni: 0.000014522
p_wrong: 1.27e-7
Score: 0.84
Data Source: BioPlex,STRINGDB
COMMD6
Tbio
Novelty: 0.11854363
p_int: 0.999982907
p_ni: 0.000017082
p_wrong: 1.1e-8
Score: 0.823
Data Source: BioPlex,STRINGDB
COMMD4
Tbio
Novelty: 0.20453574
p_int: 0.999968064
p_ni: 0.000031936
Score: 0.867
Data Source: BioPlex,STRINGDB
COMMD10
Tbio
Novelty: 0.29057641
p_int: 0.999848451
p_ni: 0.000151529
p_wrong: 2e-8
Score: 0.834
Data Source: BioPlex,STRINGDB
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.999563005
p_ni: 0.000315162
p_wrong: 0.000121833
Data Source: BioPlex
FAM45A
Tdark
Novelty: 0.94034891
p_int: 0.999168526
p_ni: 0.000831469
p_wrong: 5e-9
Score: 0.87
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.994395394
p_ni: 0.005508298
p_wrong: 0.000096308
Data Source: BioPlex
Publication Statistics
PubMed Score  17.64

PubMed score by year
PubTator Score  9.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer