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Tbio
ABCD2
ATP-binding cassette sub-family D member 2

Protein Summary
Description
Probable transporter. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308666
  • ENSP00000310688
  • ENSG00000173208

Symbol
  • ALD1
  • ALDL1
  • ALDR
  • ALDRP
  • ALDR
  • ABC39
  • ALDL1
  • ALDRP
  • hALDR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.75
histone modification site profile
0.75
protein domain
0.73
microRNA
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.7   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.7   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (39)
ABC transporters in lipid homeostasis (R-HSA-1369062)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporters in lipid homeostasis
Reactome
ABC-family proteins mediated transport
Reactome
Class I peroxisomal membrane protein import
Reactome
Protein localization
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC transporters in lipid homeostasis
ABC-family proteins mediated transport
Class I peroxisomal membrane protein import
Protein localization
Transport of small molecules
Protein-Protein Interactions (74)
1 – 10 of 74
PEX19
Tbio
Novelty: 0.00605342
Score: 0.976
Data Source: Reactome,STRINGDB
PEX3
Tbio
Novelty: 0.01171119
Score: 0.963
Data Source: Reactome,STRINGDB
ABCD3
Tbio
Family: Transporter
Novelty: 0.01081462
Score: 0.946
Data Source: Reactome,STRINGDB
ABCD1
Tbio
Family: Transporter
Novelty: 0.0067013
Score: 0.944
Data Source: Reactome,STRINGDB
ACSBG1
Tbio
Family: Enzyme
Novelty: 0.00381436
Score: 0.9
Data Source: STRINGDB
SLC25A17
Tbio
Family: Transporter
Novelty: 0.00601179
Score: 0.838
Data Source: STRINGDB
SLC27A2
Tbio
Family: Transporter
Novelty: 0.01436035
Score: 0.773
Data Source: STRINGDB
HSD17B4
Tbio
Novelty: 0.00547499
Score: 0.75
Data Source: STRINGDB
ACSL6
Tbio
Family: Enzyme
Novelty: 0.0100317
Score: 0.687
Data Source: STRINGDB
PEX13
Tbio
Novelty: 0.01777214
Score: 0.66
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.70

PubMed score by year
PubTator Score  211.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer