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Tbio
ARHGAP32
Rho GTPase-activating protein 32

Protein Summary
Description
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310343
  • ENSP00000310561
  • ENSG00000134909
  • ENST00000392657
  • ENSP00000376425
  • ENST00000527272
  • ENSP00000432862

Symbol
  • GRIT
  • KIAA0712
  • RICS
  • GRIT
  • RICS
  • GC-GAP
  • PX-RICS
  • p250GAP
  • p200RhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
virus perturbation
0.83
cellular component
0.74
microRNA
0.69
cell line
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.56   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.56   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
43.6
83.3
mean platelet volume
2
2
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
43.6
83.3
mean platelet volume
2
55.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (85)
1 – 10 of 85
ASB3
Tbio
Novelty: 0.15921018
p_int: 0.95648777
p_ni: 7.19e-7
p_wrong: 0.043511511
Score: 0.325
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.971
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.959
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.959
Data Source: STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.957
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.94
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.939
Data Source: STRINGDB
RHOJ
Tbio
Family: Enzyme
Novelty: 0.01217051
Score: 0.933
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.933
Data Source: STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.56

PubMed score by year
PubTator Score  42.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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