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Tbio
KCNE3
Potassium voltage-gated channel subfamily E member 3

Protein Summary
Description
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:12954870). Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310128
  • ENSP00000310557
  • ENSG00000175538
  • ENST00000525550
  • ENSP00000433633

Symbol
  • HYPP
  • HOKPP
  • MiRP2
  • BRGDA6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
gene perturbation
0.68
PubMedID
0.64
histone modification site profile
0.59
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.7   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.7   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.989
Data Source:  STRINGDB
KCNH2
Tclin
Family:  IC
Novelty:  0.00041611
Score:  0.967
Data Source:  STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
Score:  0.963
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.904
Data Source:  STRINGDB
KCNE2
Tbio
Family:  IC
Novelty:  0.0073267
Score:  0.884
Data Source:  STRINGDB
KCNE1
Tchem
Family:  IC
Novelty:  0.0015463
Score:  0.871
Data Source:  STRINGDB
KCNJ13
Tchem
Family:  IC
Novelty:  0.01636495
Score:  0.86
Data Source:  STRINGDB
KCNE5
Tbio
Novelty:  0.06395873
Score:  0.843
Data Source:  STRINGDB
KCNE4
Tbio
Family:  IC
Novelty:  0.04524673
Score:  0.828
Data Source:  STRINGDB
KCNK5
Tchem
Family:  IC
Novelty:  0.00932619
Score:  0.817
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
1
1
57.3
hemoglobin measurement
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
1
57.3
hemoglobin measurement
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 3
VGNC:11852
466706
Macaque
potassium voltage-gated channel subfamily E regulatory subunit 3
718902
Mouse
MGI:1891124
57442
Rat
RGD:621384
63883
Dog
potassium voltage-gated channel subfamily E regulatory subunit 3
VGNC:42242
485197
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 3
Macaque
potassium voltage-gated channel subfamily E regulatory subunit 3
Mouse
Rat
Dog
potassium voltage-gated channel subfamily E regulatory subunit 3
Publication Statistics
PubMed Score 54.70
PubMed score by year
PubTator Score 46.89
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text