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Tbio
ARHGAP1
Rho GTPase-activating protein 1

Protein Summary
Description
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311956
  • ENSP00000310491
  • ENSG00000175220

Symbol
  • CDC42GAP
  • RHOGAP1
  • RHOGAP
  • RHOGAP1
  • CDC42GAP
  • p50rhoGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.91
transcription factor binding site profile
0.86
histone modification site profile
0.81
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.93   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.93   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
85.6
1
1
0
1.1
84.2
chronotype measurement
1
1
1
51.4
reaction time measurement
1
1
1
32
femoral neck bone mineral density
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
85.6
0
1.1
84.2
chronotype measurement
1
51.4
reaction time measurement
1
32
femoral neck bone mineral density
1
29
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Protein-Protein Interactions (125)
1 – 10 of 125
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.999848842
p_ni: 0.000151152
p_wrong: 6e-9
Data Source: BioPlex
FOXR2
Tbio
Family: TF
Novelty: 0.06548862
p_int: 0.999820076
p_ni: 0.000179924
Score: 0.177
Data Source: BioPlex,STRINGDB
FGB
Tbio
Novelty: 0.00437751
p_int: 0.994661342
p_ni: 0.005338426
p_wrong: 2.32e-7
Data Source: BioPlex
FBXO25
Tbio
Novelty: 0.1205608
p_int: 0.987398744
p_ni: 0.012588042
p_wrong: 0.000013214
Score: 0.516
Data Source: BioPlex,STRINGDB
FSD1
Tbio
Novelty: 0.03452477
p_int: 0.955238663
p_ni: 0.044759822
p_wrong: 0.000001515
Data Source: BioPlex
SETX
Tbio
Family: Enzyme
Novelty: 0.00474094
p_int: 0.911580815
p_ni: 0.085489283
p_wrong: 0.002929902
Score: 0.189
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.998
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.997
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.977
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.93

PubMed score by year
PubTator Score  126.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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