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Tchem
RASGRP1
RAS guanyl-releasing protein 1

Protein Summary
Description
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332). This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310803
  • ENSP00000310244
  • ENSG00000172575
  • ENST00000414708
  • ENSP00000413105
  • ENST00000450598
  • ENSP00000388540
  • ENST00000558164
  • ENSP00000454164
  • ENST00000559830
  • ENSP00000452721

Symbol
  • RASGRP
  • RASGRP
  • CALDAG-GEFI
  • CALDAG-GEFII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
0.99
PubMedID
0.93
transcription factor perturbation
0.91
biological process
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.79   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.79   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
6
3
1.1
97.9
4
2
2
1.1
86.1
autoimmune thyroid disease
1
1
0
1.1
66.4
1
1
0
1.1
51.3
Thyroid preparation use measurement
1
1
1
46.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
97.9
2
1.1
86.1
autoimmune thyroid disease
0
1.1
66.4
0
1.1
51.3
Thyroid preparation use measurement
1
46.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS guanyl releasing protein 1
VGNC:7526
453316
Macaque
RAS guanyl releasing protein 1
703838
Mouse
MGI:1314635
19419
Rat
RGD:3539
29434
Horse
RAS guanyl releasing protein 1
VGNC:22201
100071578
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS guanyl releasing protein 1
Macaque
RAS guanyl releasing protein 1
Mouse
Rat
Horse
RAS guanyl releasing protein 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95267-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (182)
Activation of RAS in B cells (R-HSA-1169092)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAS in B cells
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Reactome
Effects of PIP2 hydrolysis
Name
Explore in Pharos
Explore in Source
Activation of RAS in B cells
Adaptive Immune System
Cytokine Signaling in Immune system
Downstream signaling events of B Cell Receptor (BCR)
Effects of PIP2 hydrolysis
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (119)
1 – 10 of 119
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.987
Data Source: Reactome,STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.963
Data Source: Reactome,STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.961
Data Source: Reactome,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.957
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.956
Data Source: Reactome,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00786502
Score: 0.952
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00111834
Score: 0.923
Data Source: STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00154917
Score: 0.921
Data Source: STRINGDB
PRKCQ
Tchem
Family: Kinase
Novelty: 0.00562719
Score: 0.918
Data Source: STRINGDB
RASGRP2
Tbio
Novelty: 0.01972105
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  146.79

PubMed score by year
PubTator Score  70.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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