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Tbio
CD34
Hematopoietic progenitor cell antigen CD34

Protein Summary
Description
Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310833
  • ENSP00000310036
  • ENSG00000174059
  • ENST00000356522
  • ENSP00000348916
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
disease perturbation
0.96
gene perturbation
0.84
cellular component
0.79
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18409.18   (req: < 5)
Gene RIFs: 279   (req: <= 3)
Antibodies: 2915   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18409.18   (req: >= 5)
Gene RIFs: 279   (req: > 3)
Antibodies: 2915   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
1
1
5.8
71.4
age at onset
1
1
0
5.8
19.3
Myopia
1
1
0
5.8
19.3
risk-taking behaviour
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
5.8
71.4
age at onset
0
5.8
19.3
Myopia
0
5.8
19.3
risk-taking behaviour
1
15.5
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (50)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (509)
1 – 10 of 509
SELL
Tchem
Novelty: 0.00030025
Score: 0.954
Data Source: Reactome,STRINGDB
PROM1
Tbio
Novelty: 0.00037987
Score: 0.938
Data Source: STRINGDB
PECAM1
Tbio
Novelty: 0.00013373
Score: 0.933
Data Source: STRINGDB
THY1
Tbio
Novelty: 0.00032846
Score: 0.931
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.93
Data Source: STRINGDB
ENG
Tbio
Novelty: 0.00036729
Score: 0.928
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.925
Data Source: STRINGDB
CSF3
Tbio
Novelty: 0.00011283
Score: 0.92
Data Source: STRINGDB
NT5E
Tchem
Family: Enzyme
Novelty: 0.00083237
Score: 0.9
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.899
Data Source: STRINGDB
Publication Statistics
PubMed Score  18409.18

PubMed score by year
PubTator Score  12545.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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