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Tbio
ACO1
Cytoplasmic aconitate hydratase

Protein Summary
Description
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309951
  • ENSP00000309477
  • ENSG00000122729
  • ENST00000379923
  • ENSP00000369255
  • ENST00000541043
  • ENSP00000438733

Symbol
  • IREB1
  • IRP1
  • ACONS
  • HEL60
  • IREB1
  • IREBP
  • IREBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.99
disease perturbation
0.93
transcription factor perturbation
0.91
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.3   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 528   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.3   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
4
4
87.5
hemoglobin measurement
3
4
4
86.1
erythrocyte count
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
87.5
hemoglobin measurement
4
86.1
erythrocyte count
1
3.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (77)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Transport of small molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (149)
1 – 10 of 149
CS
Tbio
Family: Enzyme
Novelty: 0.00154214
Score: 0.981
Data Source: STRINGDB
IDH1
Tclin
Family: Enzyme
Novelty: 0.0004831
Score: 0.971
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.97
Data Source: STRINGDB
ACLY
Tclin
Family: Enzyme
Novelty: 0.00114812
Score: 0.958
Data Source: STRINGDB
IDH3A
Tbio
Family: Enzyme
Novelty: 0.02027198
Score: 0.957
Data Source: STRINGDB
IDH3G
Tbio
Family: Enzyme
Novelty: 0.04861242
Score: 0.955
Data Source: STRINGDB
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
Score: 0.955
Data Source: STRINGDB
GLRX3
Tbio
Novelty: 0.0096265
Score: 0.951
Data Source: STRINGDB
ACO2
Tbio
Family: Enzyme
Novelty: 0.00276725
Score: 0.86
Data Source: STRINGDB
FBXL5
Tbio
Novelty: 0.03103624
Score: 0.819
Data Source: STRINGDB
Publication Statistics
PubMed Score  520.30

PubMed score by year
PubTator Score  250

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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