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Tbio
RBFOX1
RNA binding protein fox-1 homolog 1

Protein Summary
Description
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311745
  • ENSP00000309117
  • ENSG00000078328
  • ENST00000355637
  • ENSP00000347855
  • ENST00000436368
  • ENSP00000402745
  • ENST00000547338
  • ENSP00000447717
  • ENST00000550418
  • ENSP00000450031
  • ENST00000553186
  • ENSP00000447753

Symbol
  • A2BP
  • A2BP1
  • FOX1
  • HRNBP1
  • 2BP1
  • FOX1
  • A2BP1
  • FOX-1
  • HRNBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
phenotype
0.87
transcription factor
0.83
disease
0.7
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.21   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.21   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
6
5
9.8
99.5
unipolar depression
6
7
1
1
98.9
neuroticism measurement
4
7
4
7.2
96.7
wellbeing measurement
4
5
10
96.5
depressive symptom measurement
3
6
7
96.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
5
9.8
99.5
unipolar depression
1
1
98.9
neuroticism measurement
4
7.2
96.7
wellbeing measurement
10
96.5
depressive symptom measurement
7
96.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding fox-1 homolog 1
VGNC:13786
453899
Macaque
RNA binding fox-1 homolog 1
713147
Mouse
MGI:1926224
268859
Rat
RGD:1311210
302920
Dog
RNA binding fox-1 homolog 1
VGNC:45398
609116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding fox-1 homolog 1
Macaque
RNA binding fox-1 homolog 1
Mouse
Rat
Dog
RNA binding fox-1 homolog 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NWB1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
MECP2 regulates transcription factors
Reactome
RNA Polymerase II Transcription
Reactome
Transcriptional Regulation by MECP2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
MECP2 regulates transcription factors
RNA Polymerase II Transcription
Transcriptional Regulation by MECP2
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (200)
1 – 10 of 200
RNF25
Tbio
Family: Enzyme
Novelty: 0.08945219
p_int: 0.999778657
p_ni: 0.000221338
p_wrong: 4e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
MKRN1
Tbio
Family: Enzyme
Novelty: 0.04485183
p_int: 0.979079688
p_ni: 0.002831576
p_wrong: 0.018088737
Score: 0.19
Data Source: BioPlex,STRINGDB
PRMT5
Tchem
Family: Epigenetic
Novelty: 0.00395474
p_int: 0.972328132
p_ni: 0.027671868
Score: 0.208
Data Source: BioPlex,STRINGDB
COPRS
Tbio
Novelty: 0.03545787
p_int: 0.963325734
p_ni: 0.000508208
p_wrong: 0.036166058
Score: 0.183
Data Source: BioPlex,STRINGDB
SDR9C7
Tbio
Family: Enzyme
Novelty: 0.01618496
p_int: 0.962580498
p_ni: 0.037296435
p_wrong: 0.000123067
Score: 0.181
Data Source: BioPlex,STRINGDB
CAPNS2
Tbio
Novelty: 0.45658116
p_int: 0.951908216
p_ni: 0.003767984
p_wrong: 0.044323799
Score: 0.177
Data Source: BioPlex,STRINGDB
RIOK1
Tchem
Family: Kinase
Novelty: 0.02476698
p_int: 0.940335247
p_ni: 0.059664753
Score: 0.177
Data Source: BioPlex,STRINGDB
IMPA2
Tbio
Family: Enzyme
Novelty: 0.03983031
p_int: 0.930268122
p_ni: 0.019030013
p_wrong: 0.050701865
Score: 0.187
Data Source: BioPlex,STRINGDB
CTSV
Tchem
Family: Enzyme
Novelty: 0.00916301
p_int: 0.873013936
p_ni: 0.126973302
p_wrong: 0.000012761
Data Source: BioPlex
ECM1
Tbio
Novelty: 0.00518679
p_int: 0.778687134
p_ni: 0.221288449
p_wrong: 0.000024417
Data Source: BioPlex
Publication Statistics
PubMed Score  183.21

PubMed score by year
PubTator Score  83.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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