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Tbio
GMPPB
Mannose-1-phosphate guanyltransferase beta

Protein Summary
Description
Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308375
  • ENSP00000309092
  • ENSG00000173540
  • ENST00000308388
  • ENSP00000311130
  • ENST00000480687
  • ENSP00000418565

Symbol
  • LGMDR19
  • MDDGA14
  • MDDGB14
  • MDDGC14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.86
phenotype
0.73
transcription factor perturbation
0.68
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Synthesis of GDP-mannose
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
Post-translational protein modification
Synthesis of GDP-mannose
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (109)
1 – 10 of 109
GMPPA
Tbio
Family: Enzyme
Novelty: 0.02186598
p_int: 0.998291508
p_ni: 0.001708492
Score: 0.996
Data Source: BioPlex,STRINGDB
PRUNE1
Tchem
Novelty: 0.00162167
p_int: 0.998164019
p_ni: 0.001778771
p_wrong: 0.00005721
Score: 0.529
Data Source: BioPlex,STRINGDB
PI4K2B
Tbio
Family: Enzyme
Novelty: 0.68126521
p_int: 0.993972612
p_ni: 0.006027388
Score: 0.224
Data Source: BioPlex,STRINGDB
PRMT3
Tchem
Family: Epigenetic
Novelty: 0.03998365
p_int: 0.993323583
p_ni: 0.005882722
p_wrong: 0.000793695
Score: 0.311
Data Source: BioPlex,STRINGDB
GOLPH3
Tbio
Novelty: 0.00023848
p_int: 0.97858246
p_ni: 0.02141754
Score: 0.649
Data Source: BioPlex,STRINGDB
CCNB2
Tbio
Novelty: 0.01021878
p_int: 0.776519564
p_ni: 0.00999454
p_wrong: 0.213485897
Score: 0.253
Data Source: BioPlex,STRINGDB
DPM1
Tbio
Family: Enzyme
Novelty: 0.00333047
Score: 0.979
Data Source: STRINGDB
PMM2
Tchem
Family: Enzyme
Novelty: 0.00714954
Score: 0.969
Data Source: STRINGDB
PMM1
Tbio
Family: Enzyme
Novelty: 0.032216
Score: 0.967
Data Source: STRINGDB
GMDS
Tbio
Family: Enzyme
Novelty: 0.00474944
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.94

PubMed score by year
PubTator Score  17.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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