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Tbio
RNASEH2C
Ribonuclease H2 subunit C

Protein Summary
Description
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308418
  • ENSP00000308193
  • ENSG00000172922
  • ENST00000531596
  • ENSP00000435717
  • ENST00000534482
  • ENSP00000432081
  • ENST00000644142
  • ENSP00000493695

Symbol
  • AYP1
  • AGS3
  • AYP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
kinase perturbation
0.81
disease perturbation
0.74
transcription factor binding site profile
0.64
small molecule perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
1
3
83.9
balding measurement
1
1
1
24.8
triglyceride measurement
1
1
1
19.6
uric acid measurement
1
1
1
10.5
1
1
0
1.2
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
83.9
balding measurement
1
24.8
triglyceride measurement
1
19.6
uric acid measurement
1
10.5
0
1.2
4.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H2 subunit C
VGNC:12801
451330
Macaque
ribonuclease H2 subunit C
700330
Macaque
ribonuclease H2 subunit C pseudogene
701279
Mouse
MGI:1915459
68209
Rat
RGD:2319141
100361939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease H2 subunit C
Macaque
ribonuclease H2 subunit C
Macaque
ribonuclease H2 subunit C pseudogene
Mouse
Rat
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TDP1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (19)
1 – 10 of 19
RNASEH2B
Tbio
Family: Enzyme
Novelty: 0.02210045
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
RNASEH2A
Tbio
Family: Enzyme
Novelty: 0.00478657
p_int: 0.999999736
p_ni: 2.64e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
DLX6
Tbio
Family: TF
Novelty: 0.01455012
p_int: 0.999978361
p_ni: 0.000021636
p_wrong: 3e-9
Data Source: BioPlex
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.999852581
p_ni: 0.00000207
p_wrong: 0.000145349
Score: 0.22
Data Source: BioPlex,STRINGDB
GLUL
Tchem
Family: Enzyme
Novelty: 0.00086054
p_int: 0.751941926
p_ni: 0.248058074
Data Source: BioPlex
CCNB2
Tbio
Novelty: 0.00672914
Score: 0.842
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.829
Data Source: STRINGDB
TREX1
Tbio
Family: Enzyme
Novelty: 0.87486677
Score: 0.748
Data Source: STRINGDB
SAMHD1
Tbio
Family: Enzyme
Novelty: 0.00294595
Score: 0.739
Data Source: STRINGDB
ADAR
Tbio
Family: Enzyme
Novelty: 0.00135586
Score: 0.673
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.97

PubMed score by year
PubTator Score  5.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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