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Tbio
ATP6V0A4
V-type proton ATPase 116 kDa subunit a isoform 4

Protein Summary
Description
Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310018
  • ENSP00000308122
  • ENSG00000105929
  • ENST00000353492
  • ENSP00000253856
  • ENST00000393054
  • ENSP00000376774
  • ENST00000645515
  • ENSP00000496421

Symbol
  • ATP6N1B
  • ATP6N2
  • A4
  • STV1
  • VPH1
  • VPP2
  • RTA1C
  • RTADR
  • ATP6N2
  • RDRTA2
  • ATP6N1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.94
trait
0.75
gene perturbation
0.7
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.5   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.5   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
2
20.1
sleep duration
1
1
2
20.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
20.1
sleep duration
2
20.1
Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Insulin receptor recycling
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Insulin receptor recycling
Ion channel transport
Iron uptake and transport
Protein-Protein Interactions (86)
1 – 10 of 86
ATP6V1B1
Tchem
Family: Enzyme
Novelty: 0.01122589
Score: 0.997
Data Source: STRINGDB
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
Score: 0.993
Data Source: STRINGDB
ATP6V0C
Tbio
Family: Enzyme
Novelty: 0.01142874
Score: 0.992
Data Source: STRINGDB
ATP6V1F
Tbio
Family: Enzyme
Novelty: 0.07109314
Score: 0.992
Data Source: STRINGDB
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
Score: 0.991
Data Source: STRINGDB
ATP6V1H
Tbio
Family: Enzyme
Novelty: 0.04269105
Score: 0.991
Data Source: STRINGDB
ATP6V0B
Tbio
Family: Enzyme
Novelty: 0.06595421
Score: 0.99
Data Source: STRINGDB
ATP6V1A
Tbio
Family: Enzyme
Novelty: 0.00921474
Score: 0.99
Data Source: STRINGDB
ATP6V1B2
Tchem
Family: Enzyme
Novelty: 0.01767911
Score: 0.989
Data Source: STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.50

PubMed score by year
PubTator Score  29.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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