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Tbio
DST
Dystonin

Protein Summary
Description
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity). Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundl ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.99
transcription factor perturbation
0.99
interacting protein
0.95
cellular component
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.08   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 398.08   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
89.3
red blood cell density measurement
1
1
1
61.2
age at menarche
1
1
1
54.5
peak expiratory flow
1
1
1
47.4
forced expiratory volume
1
1
1
40.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
89.3
red blood cell density measurement
1
61.2
age at menarche
1
54.5
peak expiratory flow
1
47.4
forced expiratory volume
1
40.5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Cell junction organization
Cell-Cell communication
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (43)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (70)
1 – 10 of 70
MAPRE1
Tbio
Novelty: 0.01267772
p_int: 0.999999999
p_ni: 1e-9
Score: 0.98
Data Source: BioPlex,STRINGDB
COPS7B
Tbio
Novelty: 0.63421506
p_int: 0.999916453
p_ni: 0.000083545
p_wrong: 2e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.998879458
p_ni: 0.001120542
Score: 0.189
Data Source: BioPlex,STRINGDB
TXLNA
Tbio
Novelty: 0.02549959
p_int: 0.96306539
p_ni: 0.03645131
p_wrong: 0.0004833
Data Source: BioPlex
COL17A1
Tbio
Novelty: 0.00141446
Score: 0.994
Data Source: STRINGDB
ITGB4
Tbio
Novelty: 0.00386461
Score: 0.976
Data Source: Reactome,STRINGDB
ITGA6
Tbio
Novelty: 0.00217985
Score: 0.944
Data Source: Reactome,STRINGDB
CD151
Tbio
Novelty: 0.00295527
Score: 0.942
Data Source: Reactome,STRINGDB
LAMA3
Tbio
Novelty: 0.00733792
Score: 0.936
Data Source: Reactome,STRINGDB
PLEC
Tbio
Novelty: 0.00223244
Score: 0.933
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  398.08

PubMed score by year
PubTator Score  137.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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