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Tchem
GLUL
Glutamine synthetase

Protein Classes
Protein Summary
Description
Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311223
  • ENSP00000307900
  • ENSG00000135821
  • ENST00000331872
  • ENSP00000356537
  • ENST00000339526
  • ENSP00000344958
  • ENST00000417584
  • ENSP00000398320

Symbol
  • GLNS
  • GS
  • GLNS
  • PIG43
  • PIG59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
molecular function
1
disease perturbation
0.99
transcription factor perturbation
0.97
PubMedID
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.07   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.07   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Astrocytic Glutamate-Glutamine Uptake And Metabolism (R-HSA-210455)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Astrocytic Glutamate-Glutamine Uptake And Metabolism
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Neuronal System
Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (247)
1 – 10 of 247
TCHP
Tbio
Novelty: 0.00053696
p_int: 0.999999653
p_ni: 2e-9
p_wrong: 3.44e-7
Score: 0.541
Data Source: BioPlex,STRINGDB
NME7
Tbio
Family: Enzyme
Novelty: 0.08546782
p_int: 0.999907066
p_ni: 0.000092922
p_wrong: 1.1e-8
Score: 0.308
Data Source: BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
p_int: 0.997579272
p_ni: 0.002420727
Score: 0.497
Data Source: BioPlex,STRINGDB
DMXL2
Tbio
Novelty: 0.06848356
p_int: 0.99102745
p_ni: 0.008972295
p_wrong: 2.54e-7
Score: 0.211
Data Source: BioPlex,STRINGDB
ZFAND2B
Tbio
Novelty: 0.28286118
p_int: 0.940934685
p_ni: 0.059065315
Score: 0.19
Data Source: BioPlex,STRINGDB
C1orf94
Tdark
Novelty: 23
p_int: 0.838068305
p_ni: 0.161931695
Score: 0.187
Data Source: BioPlex,STRINGDB
LNP1
Tdark
Novelty: 0.00457285
p_int: 0.823130896
p_ni: 0.176869104
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.765637
p_ni: 0.234363
Data Source: BioPlex
RNASEH2C
Tbio
Family: Enzyme
Novelty: 0.06148299
p_int: 0.751941926
p_ni: 0.248058074
Data Source: BioPlex
GLUD1
Tbio
Family: Enzyme
Novelty: 0.00301109
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  944.07

PubMed score by year
PubTator Score  1793.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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