Protein Summary
Calretinin is a calcium-binding protein which is abundant in auditory neurons. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
- ENST00000302628
- ENSP00000307508
- ENSG00000172137
- ENST00000635371
- ENSP00000488916
- ENSG00000282830
- CAB29
- CR
- CAL2
- CAB29
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
PubMedID | 0.79 | ||
transcription factor perturbation | 0.74 | ||
biological term | 0.7 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2162.17 (req: < 5)
Gene RIFs: 76 (req: <= 3)
Antibodies: 578 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2162.17 (req: >= 5)
Gene RIFs: 76 (req: > 3)
Antibodies: 578 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0