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Tclin
P2RY12
P2Y purinoceptor 12

Protein Summary
Description
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302632
  • ENSP00000307259
  • ENSG00000169313

Symbol
  • HORK3
  • HORK3
  • P2Y12
  • ADPG-R
  • BDPLT8
  • SP1999
  • P2T(AC)
  • P2Y(AC)
  • P2Y(12)R
  • P2Y(ADP)
  • P2Y(cyc)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.91
ligand (chemical)
0.76
biological process
0.69
cell type or tissue
0.65
tissue sample
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2857.37   (req: < 5)
Gene RIFs: 171   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2857.37   (req: >= 5)
Gene RIFs: 171   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 629
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
purinergic receptor P2Y12
710036
Mouse
MGI:1918089
70839
Rat
RGD:621681
64803
Dog
purinergic receptor P2Y12
VGNC:44214
442958
Horse
purinergic receptor P2Y12
VGNC:21110
100630046
Species
Name
OMA
EggNOG
Inparanoid
Macaque
purinergic receptor P2Y12
Mouse
Rat
Dog
purinergic receptor P2Y12
Horse
purinergic receptor P2Y12
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H244-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
ADP signalling through P2Y purinoceptor 12 (R-HSA-392170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 12
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (42)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (344)
1 – 10 of 344
TTC39A
Tdark
Novelty: 0.9151453
p_int: 0.999491771
p_ni: 0.000001086
p_wrong: 0.000507143
Score: 0.224
Data Source: BioPlex,STRINGDB
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.99946444
p_ni: 0.000527683
p_wrong: 0.000007877
Data Source: BioPlex
CRELD1
Tbio
Novelty: 0.04938248
p_int: 0.9985387
p_ni: 0.001460822
p_wrong: 4.78e-7
Data Source: BioPlex
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.998029656
p_ni: 0.001970344
Data Source: BioPlex
TMEM161B
Tbio
Novelty: 0.27823549
p_int: 0.997866722
p_ni: 0.002133275
p_wrong: 4e-9
Score: 0.207
Data Source: BioPlex,STRINGDB
TTYH3
Tbio
Family: IC
Novelty: 0.21747247
p_int: 0.997657809
p_ni: 0.002342191
Data Source: BioPlex
MFSD8
Tbio
Novelty: 0.03388459
p_int: 0.997505031
p_ni: 0.002494966
p_wrong: 4e-9
Data Source: BioPlex
CERS5
Tbio
Family: TF
Novelty: 0.02984012
p_int: 0.997188815
p_ni: 0.002811011
p_wrong: 1.75e-7
Score: 0.159
Data Source: BioPlex,STRINGDB
GOLGA5
Tbio
Novelty: 0.04940885
p_int: 0.99707703
p_ni: 0.00292297
Data Source: BioPlex
NME2P1
Tdark
Family: Kinase
p_int: 0.996724241
p_ni: 0.003275759
Data Source: BioPlex
Publication Statistics
PubMed Score  2857.37

PubMed score by year
PubTator Score  1779.51

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer