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Tbio
AHSP
Alpha-hemoglobin-stabilizing protein

Protein Classes
Protein Summary
Description
Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302312
  • ENSP00000307199
  • ENSG00000169877

Symbol
  • EDRF
  • ERAF
  • EDRF
  • ERAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.57
biological term
0.54
chemical
0.42
small molecule perturbation
0.4
cell line
0.39


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.88   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.88   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (36)
1 – 10 of 36
TTLL4
Tbio
Family: Enzyme
Novelty: 0.14127442
p_int: 0.999999927
p_ni: 1.1e-8
p_wrong: 6.2e-8
Data Source: BioPlex
CDK12
Tchem
Family: Kinase
Novelty: 0.0119925
p_int: 0.990574453
p_ni: 0.009412216
p_wrong: 0.000013331
Data Source: BioPlex
PKP3
Tbio
Novelty: 0.0269462
p_int: 0.776362346
p_ni: 0.223637653
p_wrong: 1e-9
Data Source: BioPlex
HBA1
Tclin
Novelty: 0.00094113
Score: 0.987
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.975
Data Source: STRINGDB
HBD
Tbio
Novelty: 0.00203187
Score: 0.963
Data Source: STRINGDB
HBQ1
Tbio
Novelty: 0.00951181
Score: 0.949
Data Source: STRINGDB
HBE1
Tbio
Novelty: 0.00125958
Score: 0.925
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.92
Data Source: STRINGDB
EPB42
Tbio
Family: Enzyme
Novelty: 0.06393286
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.88

PubMed score by year
PubTator Score  600.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer