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Tbio
ASL
Argininosuccinate lyase

Protein Classes
Protein Summary
Description
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304874
  • ENSP00000307188
  • ENSG00000126522
  • ENST00000380839
  • ENSP00000370219
  • ENST00000395331
  • ENSP00000378740
  • ENST00000395332
  • ENSP00000378741

Symbol
  • ASAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.77
disease perturbation
0.74
transcription factor perturbation
0.74
histone modification site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.06   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 274   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.06   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Urea cycle
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (88)
1 – 10 of 88
ASS1
Tbio
Family: Enzyme
Novelty: 0.00358761
Score: 0.999
Data Source: STRINGDB
OTC
Tchem
Family: Enzyme
Novelty: 0.00544004
Score: 0.982
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.971
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.967
Data Source: STRINGDB
NAGS
Tbio
Family: Enzyme
Novelty: 0.0051524
Score: 0.962
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.954
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.947
Data Source: STRINGDB
NOS1
Tchem
Family: Enzyme
Novelty: 0.00032064
Score: 0.945
Data Source: STRINGDB
AZIN2
Tbio
Family: Enzyme
Novelty: 0.00750311
Score: 0.944
Data Source: STRINGDB
NOS2
Tchem
Family: Enzyme
Novelty: 0.00034846
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  141.06

PubMed score by year
PubTator Score  226.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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