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Tbio
RNF181
E3 ubiquitin-protein ligase RNF181

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306368
  • ENSP00000306906
  • ENSG00000168894

Symbol
  • HSPC238
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
kinase perturbation
0.76
transcription factor
0.69
histone modification site profile
0.67
tissue
0.65


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 181
VGNC:361
459366
Mouse
MGI:1913760
66510
Rat
RGD:1359698
297337
Dog
ring finger protein 181
VGNC:45647
475768
Horse
ring finger protein 181
VGNC:22456
100053147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 181
Mouse
Rat
Dog
ring finger protein 181
Horse
ring finger protein 181
Pathways (5)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Protein-Protein Interactions (80)
1 – 10 of 80
ICA1
Tbio
Novelty: 0.01241573
p_int: 0.999999801
p_ni: 1.95e-7
p_wrong: 4e-9
Data Source: BioPlex
RMC1
Tbio
Novelty: 0.02804116
p_int: 0.999999668
p_ni: 3.32e-7
Data Source: BioPlex
MON1B
Tbio
Novelty: 0.13486379
p_int: 0.999999491
p_ni: 5.03e-7
p_wrong: 6e-9
Data Source: BioPlex
AKIRIN2
Tbio
Novelty: 0.04603317
p_int: 0.999996669
p_ni: 0.000002891
p_wrong: 4.4e-7
Data Source: BioPlex
PICK1
Tbio
Novelty: 0.0058265
p_int: 0.99999533
p_ni: 0.000004669
p_wrong: 1e-9
Data Source: BioPlex
PSMB9
Tchem
Family: Enzyme
Novelty: 0.0016249
p_int: 0.999940506
p_ni: 0.000059416
p_wrong: 7.9e-8
Score: 0.525
Data Source: BioPlex,STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
p_int: 0.9999093
p_ni: 0.000090699
p_wrong: 1e-9
Score: 0.547
Data Source: BioPlex,STRINGDB
SLC44A5
Tdark
Family: Transporter
Novelty: 0.15262166
p_int: 0.999819288
p_ni: 0.000180707
p_wrong: 5e-9
Score: 0.266
Data Source: BioPlex,STRINGDB
LONP2
Tbio
Family: Enzyme
Novelty: 0.04499043
p_int: 0.999765514
p_ni: 0.000234486
Data Source: BioPlex
TRMT2B
Tbio
Family: Enzyme
Novelty: 0.12373575
p_int: 0.999761684
p_ni: 0.000238313
p_wrong: 3e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  4.42

PubMed score by year
PubTator Score  3.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer