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Tbio
TMEM126A
Transmembrane protein 126A

Protein Summary
Description
The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304511
  • ENSP00000306887
  • ENSG00000171202
  • ENST00000528105
  • ENSP00000436590
  • ENST00000532180
  • ENSP00000434357

Symbol
  • OPA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.83
virus perturbation
0.83
histone modification site profile
0.82
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.88   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.88   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (117)
1 – 10 of 117
LRBA
Tbio
Novelty: 0.00093369
p_int: 0.999999249
p_ni: 7.51e-7
Data Source: BioPlex
MIGA1
Tbio
Novelty: 0.08346483
p_int: 0.999991011
p_ni: 0.000008987
p_wrong: 2e-9
Data Source: BioPlex
SASS6
Tbio
Novelty: 0.00680548
p_int: 0.99998951
p_ni: 0.00001049
Data Source: BioPlex
LAMB1
Tbio
Novelty: 0.0104285
p_int: 0.999725664
p_ni: 0.000274336
Data Source: BioPlex
COLEC12
Tbio
Novelty: 0.02882427
p_int: 0.997134725
p_ni: 0.002865269
p_wrong: 6e-9
Data Source: BioPlex
GLMN
Tbio
Novelty: 0.01940401
p_int: 0.99541633
p_ni: 0.004583508
p_wrong: 1.62e-7
Data Source: BioPlex
DIAPH3
Tbio
Novelty: 0.01165283
p_int: 0.979898971
p_ni: 0.02010045
p_wrong: 5.79e-7
Score: 0.682
Data Source: BioPlex,STRINGDB
TUBGCP2
Tbio
Novelty: 0.01856674
p_int: 0.938878684
p_ni: 0.061121316
Data Source: BioPlex
IPO7
Tbio
Novelty: 0.01319011
p_int: 0.903657445
p_ni: 0.096342555
Data Source: BioPlex
CRELD2
Tbio
Novelty: 0.09438775
p_int: 0.822785551
p_ni: 0.177203079
p_wrong: 0.000011371
Data Source: BioPlex
Publication Statistics
PubMed Score  9.88

PubMed score by year
PubTator Score  8.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer