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Tchem
CXCL8
Interleukin-8

Protein Summary
Description
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307407
  • ENSP00000306512
  • ENSG00000169429

Symbol
  • IL8
  • IL8
  • NAF
  • GCP1
  • LECT
  • LUCT
  • NAP1
  • GCP-1
  • LYNAP
  • MDNCF
  • MONAP
  • NAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
gene perturbation
1
PubMedID
1
biological process
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16708.99   (req: < 5)
Gene RIFs: 1814   (req: <= 3)
Antibodies: 1509   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16708.99   (req: >= 5)
Gene RIFs: 1814   (req: > 3)
Antibodies: 1509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
84.3
1
1
0
100
71.1
CXCL6 measurement
1
1
1
66.1
Ischemic stroke
1
1
0
14.3
33
eosinophil percentage of leukocytes
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
84.3
0
100
71.1
CXCL6 measurement
1
66.1
Ischemic stroke
0
14.3
33
eosinophil percentage of leukocytes
1
3.1
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 8
VGNC:8664
471205
Dog
C-X-C motif chemokine ligand 8
VGNC:39749
403850
Horse
C-X-C motif chemokine ligand 8
VGNC:49474
100037400
Cow
C-X-C motif chemokine ligand 8
VGNC:27853
280828
Pig
C-X-C motif chemokine ligand 8
396880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 8
Dog
C-X-C motif chemokine ligand 8
Horse
C-X-C motif chemokine ligand 8
Cow
C-X-C motif chemokine ligand 8
Pig
C-X-C motif chemokine ligand 8
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10145-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (97)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chemokine receptors bind chemokines
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Chemokine receptors bind chemokines
Gene Ontology Terms (37)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (877)
1 – 10 of 877
PSMD10
Tbio
Family: Enzyme
Novelty: 0.01331382
p_int: 0.773525832
p_ni: 0.226474168
Data Source: BioPlex
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.997
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.996
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.996
Data Source: STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.993
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.992
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.992
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.991
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.988
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  16708.99

PubMed score by year
PubTator Score  12509.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer