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Tbio
UQCRFS1
Cytochrome b-c1 complex subunit Rieske, mitochondrial

Protein Summary
Description
Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (PubMed:28673544). Cytochrome b-c1 complex subunit 9: Possible component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (PubMed:28673544). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer, including this fragment, called subunit 9, which corresponds to the transit peptide (PubMed:28673544). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304863
  • ENSP00000306397
  • ENSG00000169021

Symbol
  • RIP1
  • RIS1
  • RISP
  • UQCR5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.99
disease perturbation
0.93
protein domain
0.92
co-expressed gene
0.89


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.45   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.45   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
741344
Macaque
cytochrome b-c1 complex subunit Rieske, mitochondrial
700087
Mouse
MGI:1913944
66694
Rat
RGD:628838
291103
Dog
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
VGNC:53998
476503
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Macaque
cytochrome b-c1 complex subunit Rieske, mitochondrial
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P47985-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (299)
1 – 10 of 299
LYRM7
Tbio
Novelty: 0.16270565
p_int: 0.999905862
p_ni: 0.000094138
Score: 0.742
Data Source: BioPlex,STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
p_int: 0.999816252
p_ni: 0.000183748
Score: 0.201
Data Source: BioPlex,STRINGDB
UQCRC2
Tbio
Family: Enzyme
Novelty: 0.01584406
Score: 0.999
Data Source: STRINGDB
UQCRB
Tbio
Novelty: 0.02933046
Score: 0.999
Data Source: STRINGDB
UQCRQ
Tbio
Novelty: 0.04392627
Score: 0.999
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.999
Data Source: STRINGDB
UQCRC1
Tbio
Family: Enzyme
Novelty: 0.01746759
Score: 0.999
Data Source: STRINGDB
CYC1
Tbio
Novelty: 0.01369865
Score: 0.999
Data Source: STRINGDB
UQCRH
Tbio
Novelty: 0.04494433
Score: 0.999
Data Source: STRINGDB
UQCR10
Tbio
Novelty: 0.04536078
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  277.45

PubMed score by year
PubTator Score  22.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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