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Tchem
DRD5
D(1B) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304374
  • ENSP00000306129
  • ENSG00000169676

Symbol
  • DRD1B
  • DRD1L2
  • DBDR
  • DRD1B
  • DRD1L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
drug
0.91
ligand (chemical)
0.89
virus perturbation
0.83
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.18   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.18   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 16
Pathways (30)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Dopamine receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors
G alpha (s) signalling events
GPCR downstream signalling
Gene Ontology Terms (32)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (258)
1 – 10 of 258
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
Score: 0.964
Data Source: STRINGDB
ADCY2
Tbio
Family: Enzyme
Novelty: 0.01649836
Score: 0.959
Data Source: STRINGDB
ADCY7
Tbio
Family: Enzyme
Novelty: 0.00984562
Score: 0.959
Data Source: STRINGDB
ADCY4
Tbio
Family: Enzyme
Novelty: 0.00465974
Score: 0.958
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.956
Data Source: STRINGDB
ADCY1
Tchem
Family: Enzyme
Novelty: 0.01089602
Score: 0.953
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.953
Data Source: STRINGDB
ADCY8
Tbio
Family: Enzyme
Novelty: 0.00510386
Score: 0.952
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.951
Data Source: STRINGDB
ADCY6
Tchem
Family: Enzyme
Novelty: 0.00528765
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  113.18

PubMed score by year
PubTator Score  124.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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