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Tchem
SIK2
Serine/threonine-protein kinase SIK2

Protein Summary
Description
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304987
  • ENSP00000305976
  • ENSG00000170145

Symbol
  • KIAA0781
  • QIK
  • SNF1LK2
  • QIK
  • SIK-2
  • SNF1LK2
  • LOH11CR1I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
molecular function
0.95
protein domain
0.92
virus perturbation
0.92
interacting protein
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.15   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.15   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
dasatinib
chemical structure image
bosutinib
chemical structure image
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
93.8
mathematical ability
2
2
2
91.2
2
2
0
1
41.5
1
1
0
1.2
41
diastolic blood pressure
1
1
1
32.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
93.8
mathematical ability
2
91.2
0
1
41.5
0
1.2
41
diastolic blood pressure
1
32.1
Protein-Protein Interactions (41)
1 – 10 of 41
LRRC61
Tdark
Novelty: 1.45343096
p_int: 0.999995686
p_ni: 0.000004314
Data Source: BioPlex
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.05453128
p_int: 0.999963282
p_ni: 0.000036716
p_wrong: 2e-9
Score: 0.656
Data Source: BioPlex,STRINGDB
SIK1
Tchem
Family: Kinase
Novelty: 0.00523549
p_int: 0.999914533
p_ni: 0.000080763
p_wrong: 0.000004704
Score: 0.388
Data Source: BioPlex,STRINGDB
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.999075653
p_ni: 0.000924321
p_wrong: 2.6e-8
Data Source: BioPlex
PROZ
Tbio
Family: Enzyme
Novelty: 0.05629679
p_int: 0.993832175
p_ni: 0.005384717
p_wrong: 0.000783107
Score: 0.183
Data Source: BioPlex,STRINGDB
TULP2
Tdark
Family: TF
Novelty: 0.20144336
p_int: 0.986704071
p_ni: 0.012925832
p_wrong: 0.000370097
Score: 0.177
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.947245345
p_ni: 0.026209228
p_wrong: 0.026545427
Data Source: BioPlex
CRTC2
Tbio
Novelty: 0.01888215
Score: 0.987
Data Source: STRINGDB
CAB39
Tbio
Novelty: 0.01592402
Score: 0.936
Data Source: STRINGDB
STK11
Tchem
Family: Kinase
Novelty: 0.00073247
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  63.15

PubMed score by year
PubTator Score  21.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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