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Tbio
OTUD7A
OTU domain-containing protein 7A

Protein Summary
Description
Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. The protein encoded by this gene is a deubiquitinizing enzyme and possible tumor suppressor. The encoded protein acts on TNF receptor associated factor 6 (TRAF6) to control nuclear factor kappa B expression. However, this gene is downregulated by SNAIL1 in hepatocellular carcinoma cells, contributing to their progression and malignancy. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307050
  • ENSP00000305926
  • ENSG00000169918

Symbol
  • C15orf16
  • CEZANNE2
  • OTUD7
  • OTUD7
  • C15orf16
  • C16ORF15
  • CEZANNE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
molecular function
0.67
phenotype
0.6
tissue sample
0.59
disease
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
65.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
65.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase 7A
VGNC:1901
453287
Macaque
OTU deubiquitinase 7A
720680
Mouse
MGI:2158505
170711
Rat
RGD:1563721
309252
Dog
OTU deubiquitinase 7A
VGNC:44190
488697
Species
Name
OMA
EggNOG
Inparanoid
Chimp
OTU deubiquitinase 7A
Macaque
OTU deubiquitinase 7A
Mouse
Rat
Dog
OTU deubiquitinase 7A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8TE49-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (57)
1 – 10 of 57
UBA52
Tbio
Novelty: 0.01637744
Score: 0.971
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.97
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.957
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.933
Data Source: STRINGDB
MTMR10
Tdark
Novelty: 0.24626422
Score: 0.827
Data Source: STRINGDB
CHRFAM7A
Tbio
Novelty: 0.02547993
Score: 0.807
Data Source: STRINGDB
OTUD3
Tbio
Novelty: 0.11839931
Score: 0.72
Data Source: STRINGDB
ZNF629
Tdark
Family: TF
Novelty: 0.00907269
Score: 0.719
Data Source: STRINGDB
ZNF569
Tbio
Family: TF
Novelty: 0.00491531
Score: 0.719
Data Source: STRINGDB
ZNF436
Tbio
Family: TF
Novelty: 0.00892449
Score: 0.719
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.31

PubMed score by year
PubTator Score  2.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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