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Tbio
LRTOMT
Transmembrane O-methyltransferase

Protein Summary
Description
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (PubMed:18794526). Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity (By similarity). This gene has evolved in primates as a fusion of two ancestral neighboring genes, Lrrc51 and Tomt, which exist as two independent genes in rodents. The fusion gene contains some shared exons, but encodes structurally unrelated proteins, LRTOMT1 and LRTOMT2. Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1, while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTO ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307198
  • ENSP00000305742
  • ENSG00000184154
  • ENST00000435085
  • ENSP00000409789

Symbol
  • COMT2
  • TOMT
  • DFNB63
  • LRRC51
  • CFAP111
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
microRNA
0.74
transcription factor binding site profile
0.7
tissue sample
0.68
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.23   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.23   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (10)
Dopamine clearance from the synaptic cleft (R-HSA-379401)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Dopamine clearance from the synaptic cleft
Reactome
Enzymatic degradation of dopamine by COMT
Reactome
Neuronal System
Reactome
Neurotransmitter clearance
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Dopamine clearance from the synaptic cleft
Enzymatic degradation of dopamine by COMT
Neuronal System
Neurotransmitter clearance
Transmission across Chemical Synapses
Protein-Protein Interactions (83)
1 – 10 of 83
MAOA
Tclin
Family: Enzyme
Novelty: 0.00037876
Score: 0.906
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00036833
Score: 0.906
Data Source: STRINGDB
PNMT
Tchem
Family: Enzyme
Novelty: 0.00125823
Score: 0.904
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0016806
Score: 0.901
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.00609975
Score: 0.901
Data Source: STRINGDB
CYP1B1
Tchem
Novelty: 0.00109729
Score: 0.901
Data Source: STRINGDB
ALDH3A1
Tchem
Family: Enzyme
Novelty: 0.00709135
Score: 0.901
Data Source: STRINGDB
ALDH3B2
Tbio
Family: Enzyme
Novelty: 0.12504363
Score: 0.901
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.00028982
Score: 0.901
Data Source: STRINGDB
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.05626574
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.23

PubMed score by year
PubTator Score  9.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer