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Tbio
VAMP5
Vesicle-associated membrane protein 5

Protein Summary
Description
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306384
  • ENSP00000305647
  • ENSG00000168899
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
gene perturbation
0.71
PubMedID
0.66
transcription factor perturbation
0.61
tissue
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
45
reticulocyte count
1
1
1
18.8
reticulocyte measurement
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
45
reticulocyte count
1
18.8
reticulocyte measurement
1
17.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 5
VGNC:419
470422
Macaque
vesicle associated membrane protein 5
695471
Mouse
MGI:1858622
53620
Rat
RGD:620419
89818
Dog
vesicle associated membrane protein 5
VGNC:48225
482823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 5
Macaque
vesicle associated membrane protein 5
Mouse
Rat
Dog
vesicle associated membrane protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95183-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (14)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (119)
1 – 10 of 119
NBAS
Tbio
Novelty: 0.01187862
p_int: 0.999998141
p_ni: 0.000001859
Data Source: BioPlex
GOSR1
Tbio
Novelty: 0.03139481
p_int: 0.999982964
p_ni: 0.000017033
p_wrong: 4e-9
Score: 0.947
Data Source: BioPlex,STRINGDB
USE1
Tbio
Novelty: 0.00904756
p_int: 0.99995909
p_ni: 0.00004091
Score: 0.438
Data Source: BioPlex,STRINGDB
SCFD2
Tdark
Novelty: 0.38252131
p_int: 0.999945754
p_ni: 0.000054246
Data Source: BioPlex
VTI1A
Tbio
Novelty: 0.04616617
p_int: 0.999898682
p_ni: 0.000100106
p_wrong: 0.000001212
Score: 0.735
Data Source: BioPlex,STRINGDB
NAPG
Tbio
Novelty: 0.02295985
p_int: 0.999897318
p_ni: 0.000102678
p_wrong: 3e-9
Score: 0.641
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999782481
p_ni: 0.000217519
Score: 0.812
Data Source: BioPlex,STRINGDB
SNAP47
Tdark
Novelty: 0.04348513
p_int: 0.999776262
p_ni: 0.000223738
Score: 0.727
Data Source: BioPlex,STRINGDB
BNIP1
Tbio
Novelty: 0.04601895
p_int: 0.99977514
p_ni: 0.00022486
Score: 0.599
Data Source: BioPlex,STRINGDB
STX10
Tbio
Novelty: 0.05193552
p_int: 0.999731934
p_ni: 0.000268063
p_wrong: 3e-9
Score: 0.762
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.21

PubMed score by year
PubTator Score  5.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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