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Tclin
ADRB2
Beta-2 adrenergic receptor

Protein Summary
Description
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological process
0.99
virus perturbation
0.99
gene perturbation
0.98
biological term
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2564.43   (req: < 5)
Gene RIFs: 654   (req: <= 3)
Antibodies: 1027   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2564.43   (req: >= 5)
Gene RIFs: 654   (req: > 3)
Antibodies: 1027   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 452
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 48
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
67.6
peak expiratory flow
1
1
1
56.9
forced expiratory volume
1
1
1
55.8
eosinophil percentage of leukocytes
1
2
2
29.9
eosinophil count
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
67.6
peak expiratory flow
1
56.9
forced expiratory volume
1
55.8
eosinophil percentage of leukocytes
2
29.9
eosinophil count
1
1.1
Protein Data Bank (23)
1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Cargo recognition for clathrin-mediated endocytosis
Class A/1 (Rhodopsin-like receptors)
Clathrin-mediated endocytosis
Gene Ontology Terms (55)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (391)
1 – 10 of 391
ARRB1
Tbio
Novelty: 0.00262758
Score: 0.995
Data Source: Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.991
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.991
Data Source: STRINGDB
ARRB2
Tbio
Novelty: 0.00148149
Score: 0.981
Data Source: Reactome,STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.981
Data Source: Reactome,STRINGDB
GRK5
Tchem
Family: Kinase
Novelty: 0.01108012
Score: 0.975
Data Source: Reactome,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.969
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.969
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.969
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  2564.43

PubMed score by year
PubTator Score  2895.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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