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Tbio
IL13
Interleukin-13

Protein Classes
Protein Summary
Description
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304506
  • ENSP00000304915
  • ENSG00000169194

Symbol
  • NC30
  • P600
  • IL-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
0.98
co-expressed gene
0.98
phenotype
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2105.46   (req: < 5)
Gene RIFs: 448   (req: <= 3)
Antibodies: 1040   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2105.46   (req: >= 5)
Gene RIFs: 448   (req: > 3)
Antibodies: 1040   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-4 and Interleukin-13 signaling
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (412)
1 – 10 of 412
IL4R
Tclin
Novelty: 0.00547841
Score: 0.998
Data Source: Reactome,STRINGDB
IL13RA1
Tbio
Novelty: 0.03405858
Score: 0.996
Data Source: Reactome,STRINGDB
IL13RA2
Tbio
Novelty: 0.04900852
Score: 0.996
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001974
Score: 0.992
Data Source: STRINGDB
STAT6
Tchem
Family: TF
Novelty: 0.00118956
Score: 0.99
Data Source: Reactome,STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00087325
Score: 0.99
Data Source: STRINGDB
IL6
Tclin
Novelty: 0.00002829
Score: 0.988
Data Source: STRINGDB
VCAM1
Tchem
Novelty: 0.00027927
Score: 0.987
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.983
Data Source: STRINGDB
CCL2
Tchem
Novelty: 0.00013411
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  2105.46

PubMed score by year
PubTator Score  2182.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSI
1-70
NLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLF
70-140
REGRFN
140-146
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN