Protein Classes
Protein Summary
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gen ...more
- ENST00000304506
- ENSP00000304915
- ENSG00000169194
- NC30
- P600
- IL-13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 0.98 | ||
co-expressed gene | 0.98 | ||
phenotype | 0.92 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2105.46 (req: < 5)
Gene RIFs: 448 (req: <= 3)
Antibodies: 1040 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2105.46 (req: >= 5)
Gene RIFs: 448 (req: > 3)
Antibodies: 1040 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (30)
Reactome (6)
KEGG (8)
PathwayCommons (11)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-1 family signaling | ||||
Reactome | Interleukin-18 signaling | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-1 family signaling | ||||
Interleukin-18 signaling | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Gene Ontology Terms (34)
Functions (2)
Components (4)
Processes (28)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (412)
1 – 10 of 412
IL4R
Novelty: 0.00547841
Score: 0.998
Data Source: Reactome,STRINGDB
IL13RA1
Novelty: 0.03405858
Score: 0.996
Data Source: Reactome,STRINGDB
IL13RA2
Novelty: 0.04900852
Score: 0.996
Data Source: Reactome,STRINGDB
TNF
Novelty: 0.00001974
Score: 0.992
Data Source: STRINGDB
STAT6
Family: TF
Novelty: 0.00118956
Score: 0.99
Data Source: Reactome,STRINGDB
GATA3
Family: TF
Novelty: 0.00087325
Score: 0.99
Data Source: STRINGDB
IL6
Novelty: 0.00002829
Score: 0.988
Data Source: STRINGDB
VCAM1
Novelty: 0.00027927
Score: 0.987
Data Source: STRINGDB
CXCL8
Novelty: 0.00009183
Score: 0.983
Data Source: STRINGDB
CCL2
Novelty: 0.00013411
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score 2105.46
PubMed score by year
PubTator Score 2182.73
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSI
1-70
NLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLF
70-140
REGRFN
140-146
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN
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