Tbio IL13 Interleukin-13

Protein Classes

DTO Classes

Interleukin-13 Receptor Subunit Alpha-1 / Interleukin-13 Receptor Subunit Alpha-2

Protein Summary

Description

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity). This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35225
• O43644
• Q4VB52
• Q9UDC7
• IL-13

Gene Name

• IL13

Ensembl ID

• ENST00000304506
• ENSP00000304915
• ENSG00000169194

Symbol

• NC30
• P600
• IL-13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	0.98
co-expressed gene	0.98
phenotype	0.92

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2105.46   (req: < 5)

Gene RIFs: 448   (req: <= 3)

Antibodies: 1040   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2105.46   (req: >= 5)

Gene RIFs: 448   (req: > 3)

Antibodies: 1040   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (15)

1 – 5 of 15

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (30)

Reactome (6)

KEGG (8)

PathwayCommons (11)

WikiPathways (5)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-1 family signaling	140 targets	R-HSA-446652
Reactome	Interleukin-18 signaling	8 targets	R-HSA-9012546
Reactome	Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-1 family signaling	140 targets	R-HSA-446652
Interleukin-18 signaling	8 targets	R-HSA-9012546
Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807

Gene Ontology Terms (34)

Functions (2)

Components (4)

Processes (28)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
interleukin-13 receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (412)

Explore Interacting Targets

1 – 10 of 412

• See Interactions on String-DB

IL4R

Tclin

Novelty: 0.00547841

Score: 0.998

Data Source: Reactome,STRINGDB

IL13RA1

Tbio

Novelty: 0.03405858

Score: 0.996

Data Source: Reactome,STRINGDB

IL13RA2

Tbio

Novelty: 0.04900852

Score: 0.996

Data Source: Reactome,STRINGDB

TNF

Tclin

Novelty: 0.00001974

Score: 0.992

Data Source: STRINGDB

STAT6

Tchem

Family: TF

Novelty: 0.00118956

Score: 0.99

Data Source: Reactome,STRINGDB

GATA3

Tbio

Family: TF

Novelty: 0.00087325

Score: 0.99

Data Source: STRINGDB

IL6

Tclin

Novelty: 0.00002829

Score: 0.988

Data Source: STRINGDB

VCAM1

Tchem

Novelty: 0.00027927

Score: 0.987

Data Source: STRINGDB

CXCL8

Tchem

Novelty: 0.00009183

Score: 0.983

Data Source: STRINGDB

CCL2

Tchem

Novelty: 0.00013411

Score: 0.981

Data Source: STRINGDB

Publication Statistics

PubMed Score  2105.46

PubMed score by year

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PubTator Score  2182.73

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSI

1-70

NLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLF

70-140

REGRFN

140-146

MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAPLCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRDTKIEVAQFVKDLLLHLKKLFREGRFN

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