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Tbio
FAM83B
Protein FAM83B

Protein Summary
Description
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306858
  • ENSP00000304078
  • ENSG00000168143

Symbol
  • C6orf143
  • C6orf143
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.59
cell line
0.57
cell type or tissue
0.55
interacting protein
0.51
drug perturbation
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1
93.7
age at menarche
1
1
1
59.3
glomerular filtration rate
1
1
1
35.5
blood urea nitrogen measurement
1
1
1
34.2
creatinine measurement
1
1
1
33.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
93.7
age at menarche
1
59.3
glomerular filtration rate
1
35.5
blood urea nitrogen measurement
1
34.2
creatinine measurement
1
33.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 83 member B
VGNC:2825
462785
Macaque
family with sequence similarity 83 member B
711574
Mouse
MGI:2685362
208994
Rat
RGD:1311988
315829
Dog
family with sequence similarity 83 member B
VGNC:40700
481850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 83 member B
Macaque
family with sequence similarity 83 member B
Mouse
Rat
Dog
family with sequence similarity 83 member B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q5T0W9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (29)
1 – 10 of 29
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.999999971
p_ni: 2.7e-8
p_wrong: 2e-9
Data Source: BioPlex
CLEC11A
Tbio
Novelty: 0.03060601
p_int: 0.999931954
p_ni: 0.000026985
p_wrong: 0.000041061
Score: 0.21
Data Source: BioPlex,STRINGDB
ARC
Tbio
Novelty: 0.00378953
p_int: 0.999874511
p_ni: 0.000050942
p_wrong: 0.000074548
Score: 0.416
Data Source: BioPlex,STRINGDB
IMPG1
Tbio
Novelty: 0.03770903
Score: 0.67
Data Source: STRINGDB
KLHL31
Tbio
Novelty: 0.10153296
Score: 0.655
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.596
Data Source: STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.593
Data Source: STRINGDB
FILIP1
Tdark
Novelty: 0.10357433
Score: 0.584
Data Source: STRINGDB
MYO5C
Tbio
Novelty: 0.05680943
Score: 0.58
Data Source: STRINGDB
TINAG
Tbio
Novelty: 0.04582927
Score: 0.571
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.63

PubMed score by year
PubTator Score  4.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer