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Tbio
HTRA3
Serine protease HTRA3

Protein Summary
Description
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307358
  • ENSP00000303766
  • ENSG00000170801
  • ENST00000382512
  • ENSP00000371952

Symbol
  • PRSP
  • Prsp
  • Tasp
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
small molecule perturbation
0.58
tissue
0.58
cell line
0.55
tissue sample
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (12)
1 – 10 of 12
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.999999159
p_ni: 5.19e-7
p_wrong: 3.22e-7
Score: 0.243
Data Source: BioPlex,STRINGDB
SPCS3
Tbio
Family: Enzyme
Novelty: 0.13677259
p_int: 0.999805282
p_ni: 0.000067849
p_wrong: 0.00012687
Data Source: BioPlex
ISPD
Tbio
Family: Enzyme
Novelty: 0.01137456
Score: 0.562
Data Source: STRINGDB
GPAT4
Tbio
Family: Enzyme
Novelty: 0.03409111
Score: 0.523
Data Source: STRINGDB
MVD
Tchem
Family: Enzyme
Novelty: 0.0067581
Score: 0.515
Data Source: STRINGDB
MPP7
Tbio
Novelty: 1.59072481
Score: 0.497
Data Source: STRINGDB
AGPAT3
Tbio
Family: Enzyme
Novelty: 0.06139822
Score: 0.479
Data Source: STRINGDB
CLPP
Tbio
Family: Enzyme
Novelty: 0.00105289
Score: 0.476
Data Source: STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
Score: 0.454
Data Source: STRINGDB
COL15A1
Tbio
Novelty: 0.04078006
Score: 0.44
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.36

PubMed score by year
PubTator Score  59.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer