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Tbio
LRP8
Low-density lipoprotein receptor-related protein 8

Protein Summary
Description
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306052
  • ENSP00000303634
  • ENSG00000157193
  • ENST00000347547
  • ENSP00000334522
  • ENST00000354412
  • ENSP00000346391
  • ENST00000371454
  • ENSP00000360509

Symbol
  • APOER2
  • MCI1
  • LRP-8
  • APOER2
  • HSZ75190
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological process
0.97
kinase perturbation
0.97
transcription factor perturbation
0.97
PubMedID
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.96   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.96   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Metabolism
Reactome
Metabolism of fat-soluble vitamins
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Hemostasis
Metabolism
Metabolism of fat-soluble vitamins
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (107)
1 – 10 of 107
LRPAP1
Tbio
Novelty: 0.0018518
p_int: 0.994573648
p_ni: 1e-9
p_wrong: 0.005426351
Score: 0.959
Data Source: BioPlex,STRINGDB
RELN
Tbio
Novelty: 0.00156613
Score: 0.996
Data Source: STRINGDB
APOE
Tbio
Novelty: 0.0000621
Score: 0.987
Data Source: Reactome,STRINGDB
DAB1
Tbio
Novelty: 0.1773399
Score: 0.985
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00092113
Score: 0.977
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00010107
Score: 0.95
Data Source: STRINGDB
CRKL
Tbio
Novelty: 0.0061856
Score: 0.947
Data Source: STRINGDB
RAPGEF1
Tbio
Novelty: 0.00343756
Score: 0.943
Data Source: STRINGDB
AGRN
Tbio
Novelty: 0.0018427
Score: 0.942
Data Source: STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00042857
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  154.96

PubMed score by year
PubTator Score  102.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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