Protein Classes
Protein Summary
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]
- ENST00000304883
- ENSP00000303325
- ENSG00000169836
- NK3R
- TAC3R
- NK3
- NKR
- HH11
- NK3R
- NK-3R
- TAC3R
- TAC3RL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.85 | ||
gene perturbation | 0.74 | ||
cellular component | 0.71 | ||
ligand (protein) | 0.68 | ||
virus perturbation | 0.68 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 280.17 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 339 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 280.17 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 339 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 575
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Active Ligands (575)
1 – 10 of 575
Pathways (13)
Reactome (8)
KEGG (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Gene Ontology Terms (21)
Functions (1)
Components (7)
Processes (13)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (261)
1 – 10 of 261
C6orf47
Novelty: 0.27025154
p_int: 0.999994504
p_ni: 0.000005493
p_wrong: 2e-9
Data Source: BioPlex
SNX27
Novelty: 0.02796021
p_int: 0.999960081
p_ni: 0.000039919
Data Source: BioPlex
FARP2
Novelty: 0.19204615
p_int: 0.999923549
p_ni: 0.000076409
p_wrong: 4.2e-8
Data Source: BioPlex
DMXL2
Novelty: 0.09035497
p_int: 0.999896055
p_ni: 0.000103945
Data Source: BioPlex
RAP1A
Family: Enzyme
Novelty: 0.00466391
p_int: 0.999643537
p_ni: 0.000336441
p_wrong: 0.000020022
Data Source: BioPlex
CERS5
Family: TF
Novelty: 0.04558376
p_int: 0.999544167
p_ni: 0.000065122
p_wrong: 0.000390711
Data Source: BioPlex
PPFIBP1
Novelty: 0.18266164
p_int: 0.999413557
p_ni: 0.000586443
Data Source: BioPlex
USP20
Family: Enzyme
Novelty: 0.0779104
p_int: 0.999330858
p_ni: 0.000127423
p_wrong: 0.000541719
Data Source: BioPlex
REEP6
Novelty: 0.17493781
p_int: 0.997865197
p_ni: 0.002133356
p_wrong: 0.000001448
Data Source: BioPlex
C2CD5
Novelty: 0.79395085
p_int: 0.997309444
p_ni: 0.002689284
p_wrong: 0.000001272
Data Source: BioPlex
Publication Statistics
PubMed Score 280.17
PubMed score by year
PubTator Score 132.81
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQP
1-70
WANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTL
70-140
VNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWIL
140-210
AFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIP
210-280
GDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTM
280-350
YNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
350-420
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
420-465
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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