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Tbio
MAT2A
S-adenosylmethionine synthase isoform type-2

Protein Summary
Description
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306434
  • ENSP00000303147
  • ENSG00000168906
  • ENST00000409017
  • ENSP00000386353

Symbol
  • AMS2
  • MATA2
  • MATA2
  • MATII
  • SAMS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.97
molecular function
0.9
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.19   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.19   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Methylation
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Methylation
Phase II - Conjugation of compounds
Protein-Protein Interactions (134)
1 – 10 of 134
MAT1A
Tbio
Family: Enzyme
Novelty: 0.00543557
p_int: 1
Score: 0.988
Data Source: BioPlex,STRINGDB
MAT2B
Tbio
Family: Enzyme
Novelty: 0.0671244
p_int: 0.998995226
p_ni: 0.001004774
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BHMT
Tchem
Family: Enzyme
Novelty: 0.00611995
Score: 0.974
Data Source: STRINGDB
MTR
Tbio
Family: Enzyme
Novelty: 0.00105146
Score: 0.969
Data Source: STRINGDB
BHMT2
Tchem
Family: Enzyme
Novelty: 0.10239441
Score: 0.962
Data Source: STRINGDB
AMD1
Tchem
Family: Enzyme
Novelty: 0.00107659
Score: 0.957
Data Source: STRINGDB
DNMT1
Tclin
Family: Enzyme
Novelty: 0.0005455
Score: 0.952
Data Source: STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00164012
Score: 0.929
Data Source: STRINGDB
DNMT3A
Tclin
Family: Epigenetic
Novelty: 0.0010559
Score: 0.928
Data Source: STRINGDB
TAT
Tbio
Family: Enzyme
Novelty: 0.00082991
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.19

PubMed score by year
PubTator Score  73.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGE
1-70
ITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFG
70-140
YATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHD
140-210
EEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGG
210-280
AFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVK
280-350
KNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
350-395
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY