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Tbio
HSPA4
Heat shock 70 kDa protein 4

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11271.83   (req: < 5)
Gene RIFs: 269   (req: <= 3)
Antibodies: 470   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11271.83   (req: >= 5)
Gene RIFs: 269   (req: > 3)
Antibodies: 470   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
2
3
93.7
heel bone mineral density
2
2
2
93.4
waist-hip ratio
1
1
1
81.6
triglyceride measurement
4
3
4
76.3
diastolic blood pressure
1
1
1
49.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
93.7
heel bone mineral density
2
93.4
waist-hip ratio
1
81.6
triglyceride measurement
4
76.3
diastolic blood pressure
1
49.9
Pathways (63)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (769)
1 – 10 of 769
TUSC2
Tbio
Novelty: 0.05958876
p_int: 0.998480738
p_ni: 0.001519262
Data Source: BioPlex
TCAP
Tbio
Novelty: 0.00623581
p_int: 0.883880053
p_ni: 0.116119947
Score: 0.197
Data Source: BioPlex,STRINGDB
TRMT12
Tbio
Family: Enzyme
Novelty: 0.12417204
p_int: 0.862272289
p_ni: 0.137727711
Score: 0.348
Data Source: BioPlex,STRINGDB
SLC27A3
Tbio
Family: Transporter
Novelty: 0.1037612
p_int: 0.859930918
p_ni: 0.140069082
Score: 0.239
Data Source: BioPlex,STRINGDB
SNX20
Tdark
Novelty: 0.28934317
p_int: 0.84434012
p_ni: 0.15565988
Score: 0.187
Data Source: BioPlex,STRINGDB
METTL21A
Tbio
Family: Enzyme
Novelty: 0.31897774
p_int: 0.843869876
p_ni: 0.156130124
Score: 0.699
Data Source: BioPlex,STRINGDB
KCNJ10
Tbio
Family: IC
Novelty: 0.00273462
p_int: 0.80852217
p_ni: 0.19147783
Score: 0.242
Data Source: BioPlex,STRINGDB
TTC9B
Tdark
Novelty: 0.25942345
p_int: 0.755165318
p_ni: 0.244834682
Score: 0.332
Data Source: BioPlex,STRINGDB
DNAJB1
Tbio
Novelty: 0.00139956
Score: 0.999
Data Source: STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  11271.83

PubMed score by year
PubTator Score  3912.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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