Tdark PYGO1 Pygopus homolog 1

Protein Summary

Description

Involved in signal transduction through the Wnt pathway.

Uniprot Accession IDs

• Q9Y3Y4
• A7Y2D6

Gene Name

• PYGO1

Ensembl ID

• ENST00000302000
• ENSP00000302327
• ENSG00000171016
• ENST00000563719
• ENSP00000457777
• ENST00000645724
• ENSP00000496139

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.76
protein domain	0.73
cell type or tissue	0.55
biological process	0.54
histone modification site profile	0.46

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.3   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.3   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (5)

1 – 5 of 5

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (78)

Reactome (5)

PathwayCommons (7)

WikiPathways (66)

Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Deactivation of the beta-catenin transactivating complex	42 targets	R-HSA-3769402
Reactome	Formation of the beta-catenin:TCF transactivating complex	61 targets	R-HSA-201722
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by WNT	299 targets	R-HSA-195721
Reactome	TCF dependent signaling in response to WNT	204 targets	R-HSA-201681

Name	Explore in Pharos	Explore in Source
Deactivation of the beta-catenin transactivating complex	42 targets	R-HSA-3769402
Formation of the beta-catenin:TCF transactivating complex	61 targets	R-HSA-201722
Signal Transduction	2704 targets	R-HSA-162582
Signaling by WNT	299 targets	R-HSA-195721
TCF dependent signaling in response to WNT	204 targets	R-HSA-201681

Gene Ontology Terms (11)

Functions (2)

Components (1)

Processes (8)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
methylated histone binding	Inferred from Direct Assay (IDA)	FlyBase
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (64)

Explore Interacting Targets

1 – 10 of 64

• See Interactions on String-DB

BCL9

Tbio

Novelty: 0.02276827

Score: 0.999

Data Source: Reactome,STRINGDB

HIST3H3

Tbio

Novelty: 0.09996887

Score: 0.994

Data Source: STRINGDB

CTNNB1

Tchem

Novelty: 0.00008951

Score: 0.957

Data Source: Reactome,STRINGDB

H3F3C

Tbio

Novelty: 0.07556919

Score: 0.957

Data Source: STRINGDB

H3F3A

Tbio

Novelty: 0.00644912

Score: 0.957

Data Source: STRINGDB

BCL9L

Tbio

Novelty: 0.08549112

Score: 0.956

Data Source: Reactome,STRINGDB

LEF1

Tchem

Family: TF

Novelty: 0.00223818

Score: 0.955

Data Source: Reactome,STRINGDB

HIST2H3A

Tbio

Novelty: 0.04593632

Score: 0.949

Data Source: STRINGDB

HIST1H3A

Tbio

Novelty: 0.01912636

Score: 0.947

Data Source: STRINGDB

HIST2H2AC

Tbio

Novelty: 0.00121358

Score: 0.935

Data Source: STRINGDB

Publication Statistics

PubMed Score  3.30

PubMed score by year

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PubTator Score  3.67

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAAN

1-70

PFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGF

70-140

NRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNS

140-210

NFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNN

210-280

AVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEV

280-350

NDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA

350-419

MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Metal-binding
Nucleus
Polymorphism
Reference proteome
Wnt signaling pathway
Zinc
Zinc-finger