Protein Summary
Involved in signal transduction through the Wnt pathway.
- ENST00000302000
- ENSP00000302327
- ENSG00000171016
- ENST00000563719
- ENSP00000457777
- ENST00000645724
- ENSP00000496139
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.76 | ||
protein domain | 0.73 | ||
cell type or tissue | 0.55 | ||
biological process | 0.54 | ||
histone modification site profile | 0.46 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.3 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 153 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.3 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 153 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (78)
Reactome (5)
PathwayCommons (7)
WikiPathways (66)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Deactivation of the beta-catenin transactivating complex | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | TCF dependent signaling in response to WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Deactivation of the beta-catenin transactivating complex | ||||
Formation of the beta-catenin:TCF transactivating complex | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
TCF dependent signaling in response to WNT | ||||
Gene Ontology Terms (11)
Functions (2)
Components (1)
Processes (8)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (64)
1 – 10 of 64
BCL9
Novelty: 0.02276827
Score: 0.999
Data Source: Reactome,STRINGDB
HIST3H3
Novelty: 0.09996887
Score: 0.994
Data Source: STRINGDB
CTNNB1
Novelty: 0.00008951
Score: 0.957
Data Source: Reactome,STRINGDB
H3F3C
Novelty: 0.07556919
Score: 0.957
Data Source: STRINGDB
H3F3A
Novelty: 0.00644912
Score: 0.957
Data Source: STRINGDB
BCL9L
Novelty: 0.08549112
Score: 0.956
Data Source: Reactome,STRINGDB
LEF1
Family: TF
Novelty: 0.00223818
Score: 0.955
Data Source: Reactome,STRINGDB
HIST2H3A
Novelty: 0.04593632
Score: 0.949
Data Source: STRINGDB
HIST1H3A
Novelty: 0.01912636
Score: 0.947
Data Source: STRINGDB
HIST2H2AC
Novelty: 0.00121358
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score 3.30
PubMed score by year
PubTator Score 3.67
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAAN
1-70
PFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGF
70-140
NRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNS
140-210
NFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNN
210-280
AVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEV
280-350
NDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA
350-419
MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA
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