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Tbio
GBX2
Homeobox protein GBX-2

Protein Summary
Description
May act as a transcription factor for cell pluripotency and differentiation in the embryo.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306318
  • ENSP00000302251
  • ENSG00000168505
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.97
gene perturbation
0.9
transcription factor binding site profile
0.76
PubMedID
0.7
biological process
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.93   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.93   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gastrulation brain homeobox 2
VGNC:437
470689
Macaque
gastrulation brain homeobox 2
693901
Mouse
MGI:95668
14472
Rat
RGD:621866
114500
Dog
gastrulation brain homeobox 2
VGNC:41135
486174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gastrulation brain homeobox 2
Macaque
gastrulation brain homeobox 2
Mouse
Rat
Dog
gastrulation brain homeobox 2
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Dopaminergic Neurogenesis
WikiPathways
22q11.2 Deletion Syndrome
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Dopaminergic Neurogenesis
22q11.2 Deletion Syndrome
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (80)
1 – 10 of 80
GBX1
Tbio
Family: TF
Novelty: 0.07063263
p_int: 0.999999996
p_wrong: 4e-9
Data Source: BioPlex
FHL3
Tbio
Novelty: 0.11505924
p_int: 0.983324316
p_ni: 0.016675684
Data Source: BioPlex
CHD4
Tbio
Family: Epigenetic
Novelty: 0.00826969
p_int: 0.824995961
p_ni: 0.175004039
Data Source: BioPlex
PAX2
Tbio
Family: TF
Novelty: 0.00160808
Score: 0.826
Data Source: STRINGDB
FGF8
Tbio
Novelty: 0.00155113
Score: 0.797
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.772
Data Source: STRINGDB
LHX9
Tbio
Family: TF
Novelty: 0.02952374
Score: 0.678
Data Source: STRINGDB
KLF4
Tbio
Family: TF
Novelty: 0.00076828
Score: 0.662
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00599946
Score: 0.649
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.644
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.93

PubMed score by year
PubTator Score  17.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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