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Tchem
BIRC5
Baculoviral IAP repeat-containing protein 5

Protein Summary
Description
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a defaul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374948
  • ENSP00000364086
  • ENSG00000089685
  • ENST00000590449
  • ENSP00000465868
  • ENST00000590925
  • ENSP00000467336
  • ENST00000592734
  • ENSP00000466617

Symbol
  • API4
  • IAP4
  • API4
  • EPR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
co-expressed gene
0.95
kinase perturbation
0.95
transcription factor perturbation
0.94
biological term
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: < 5)
Gene RIFs: 1093   (req: <= 3)
Antibodies: 1598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.94   (req: >= 5)
Gene RIFs: 1093   (req: > 3)
Antibodies: 1598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (21)
1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (159)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (47)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (388)
1 – 10 of 388
CDCA8
Tbio
Novelty: 0.01448513
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCDC102A
Tdark
Novelty: 1.89784272
p_int: 0.999996758
p_ni: 0.000003242
Data Source: BioPlex
INCENP
Tbio
Novelty: 0.00704937
p_int: 0.999995311
p_ni: 5.33e-7
p_wrong: 0.000004156
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
HBZ
Tbio
Novelty: 0.00331625
p_int: 0.999960695
p_ni: 0.000039305
Score: 0.164
Data Source: BioPlex,STRINGDB
SSC5D
Tbio
Novelty: 0.23138499
p_int: 0.999725154
p_ni: 0.000248369
p_wrong: 0.000026477
Score: 0.187
Data Source: BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty: 0.24218646
p_int: 0.999467703
p_ni: 0.000532295
p_wrong: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
p_int: 0.999395489
p_ni: 0.000594992
p_wrong: 0.00000952
Score: 0.256
Data Source: BioPlex,STRINGDB
MED6
Tbio
Family: Enzyme
Novelty: 0.05215086
p_int: 0.995209194
p_ni: 0.004790806
Score: 0.702
Data Source: BioPlex,STRINGDB
MED14
Tbio
Family: Enzyme
Novelty: 0.01741917
p_int: 0.992882723
p_ni: 0.007117277
Score: 0.768
Data Source: BioPlex,STRINGDB
MED10
Tdark
Family: Enzyme
Novelty: 0.02988632
p_int: 0.991080163
p_ni: 0.008735242
p_wrong: 0.000184594
Score: 0.711
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  284.94

PubMed score by year
PubTator Score  171.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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