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Tbio
ANKRD11
Ankyrin repeat domain-containing protein 11

Protein Summary
Description
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301030
  • ENSP00000301030
  • ENSG00000167522
  • ENST00000378330
  • ENSP00000367581
  • ENST00000642600
  • ENSP00000495226

Symbol
  • ANCO1
  • T13
  • LZ16
  • ANCO1
  • ANCO-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.95
ligand (protein) perturbation
0.83
virus perturbation
0.79
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.77   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.77   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
2
2
93.2
non-melanoma skin carcinoma
1
1
0
1.3
75
eosinophil count
2
2
2
50.1
lymphocyte count
2
1
2
23.2
keratinocyte carcinoma
1
1
0
1.1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
2
93.2
non-melanoma skin carcinoma
0
1.3
75
eosinophil count
2
50.1
lymphocyte count
2
23.2
keratinocyte carcinoma
0
1.1
21.2
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (25)
1 – 10 of 25
GPS2
Tbio
Novelty: 0.00986158
p_int: 1
Score: 0.372
Data Source: BioPlex,STRINGDB
CD6
Tbio
Novelty: 0.00309541
Score: 0.7
Data Source: STRINGDB
KMT2D
Tbio
Family: Epigenetic
Novelty: 0.00380525
Score: 0.693
Data Source: STRINGDB
ZNF778
Tdark
Family: TF
Novelty: 0.34526773
Score: 0.676
Data Source: STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.669
Data Source: STRINGDB
HDAC5
Tclin
Family: Epigenetic
Novelty: 0.00484422
Score: 0.668
Data Source: STRINGDB
NCOA3
Tbio
Family: Epigenetic
Novelty: 0.00193529
Score: 0.668
Data Source: STRINGDB
RSF1
Tbio
Family: Epigenetic
Novelty: 0.0155058
Score: 0.642
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.628
Data Source: STRINGDB
HDAC4
Tclin
Family: Epigenetic
Novelty: 0.00217749
Score: 0.627
Data Source: STRINGDB
Publication Statistics
PubMed Score  96.77

PubMed score by year
PubTator Score  147.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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