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Tchem
MVD
Diphosphomevalonate decarboxylase

Protein Summary
Description
Performs the first committed step in the biosynthesis of isoprenes. The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301012
  • ENSP00000301012
  • ENSG00000167508

Symbol
  • MPD
  • MPD
  • MDDase
  • POROK7
  • FP17780
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
histone modification site profile
0.91
protein domain
0.85
gene perturbation
0.71
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.09   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.09   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (16)
1 – 10 of 16
CHEMBL1160330
chemical structure image
CHEMBL1160328
chemical structure image
CHEMBL1160332
chemical structure image
CHEMBL1160329
chemical structure image
CHEMBL1160331
chemical structure image
CHEMBL1160294
chemical structure image
compound 18 [PMID: 17888661]
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Cholesterol biosynthesis
Metabolism
Protein-Protein Interactions (99)
1 – 10 of 99
ATP6V0D1
Tbio
Family: Enzyme
Novelty: 0.05146108
p_int: 0.999999995
p_wrong: 5e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
IDI1
Tchem
Family: Enzyme
Novelty: 0.01145181
Score: 0.997
Data Source: STRINGDB
PMVK
Tchem
Family: Enzyme
Novelty: 0.00468598
Score: 0.996
Data Source: STRINGDB
FDPS
Tclin
Family: Enzyme
Novelty: 0.00164195
Score: 0.995
Data Source: STRINGDB
MVK
Tchem
Family: Kinase
Novelty: 0.00328607
Score: 0.992
Data Source: STRINGDB
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00292258
Score: 0.988
Data Source: STRINGDB
IDI2
Tbio
Family: Enzyme
Novelty: 0.02715208
Score: 0.985
Data Source: STRINGDB
LSS
Tchem
Family: Enzyme
Novelty: 0.00735187
Score: 0.978
Data Source: STRINGDB
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01089288
Score: 0.978
Data Source: STRINGDB
FDFT1
Tchem
Family: Enzyme
Novelty: 0.00225882
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  139.09

PubMed score by year
PubTator Score  283.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer