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Tbio
CKMT1A
Creatine kinase U-type, mitochondrial

Protein Summary
Description
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300283
  • ENSP00000300283
  • ENSG00000237289
  • ENST00000413453
  • ENSP00000406577
  • ENSG00000223572
  • ENST00000434505
  • ENSP00000413165
  • ENST00000441322
  • ENSP00000413255

Symbol
  • CKMT
  • CKMT
  • CKMT1
  • UMTCK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
cellular component
0.67
disease
0.59
transcription factor perturbation
0.54
interacting protein
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.51   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.51   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
57.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
57.4
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99441
12716
Rat
RGD:61976
29593
Cow
creatine kinase, mitochondrial 1B
281692
Chicken
creatine kinase, mitochondrial 1A
CGNC:48997
374002
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
creatine kinase, mitochondrial 1B
Chicken
creatine kinase, mitochondrial 1A
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12532-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Creatine metabolism (R-HSA-71288)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Creatine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Creatine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (59)
1 – 10 of 59
CKMT2
Tbio
Family: Kinase
Novelty: 0.00904745
p_int: 1
Score: 0.692
Data Source: BioPlex,STRINGDB
ASB9
Tbio
Novelty: 0.18287435
p_int: 0.999803479
p_ni: 0.000196521
Score: 0.93
Data Source: BioPlex,STRINGDB
GAMT
Tbio
Family: Enzyme
Novelty: 0.00656642
Score: 0.951
Data Source: STRINGDB
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
Score: 0.822
Data Source: STRINGDB
SLC6A8
Tbio
Family: Transporter
Novelty: 0.00332655
Score: 0.812
Data Source: STRINGDB
STRC
Tbio
Novelty: 0.01587212
Score: 0.809
Data Source: STRINGDB
CATSPER2
Tchem
Family: IC
Novelty: 0.03701031
Score: 0.809
Data Source: STRINGDB
LDHAL6A
Tbio
Family: Enzyme
Novelty: 0.01301939
Score: 0.797
Data Source: STRINGDB
CKM
Tbio
Family: Kinase
Novelty: 0.00239628
Score: 0.794
Data Source: STRINGDB
PPIP5K1
Tbio
Family: Enzyme
Novelty: 0.01175655
Score: 0.767
Data Source: STRINGDB
Publication Statistics
PubMed Score  111.51

PubMed score by year
PubTator Score  20.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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